Complications during Adolescence Predict Mortality in Young Adults with Childhood Onset Type 1 Diabetes.

Myra S Poon, Albert K F Chan, Janine M Cusumano, Maria E Craig, Kim C Donaghue

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Article in Pediatric diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Myra S PoonInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0002-3606-5848

Albert K F ChanInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Janine M CusumanoInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Maria E CraigInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0001-6004-576X

Kim C DonaghueInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.ORCID 0000-0002-4210-7872

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Microvascular complications increase the risk of cardiovascular disease and premature death in adults with type 1 diabetes. We examined the association between microvascular complications during adolescence, including cardiac autonomic nerve dysfunction and subsequent mortality. Results: At final adolescent visit, 20% had CAN abnormality, 30% abnormal pupillary response, 20% albuminuria, 40% early elevation of albumin excretion rate (AER) and 45% retinopathy. Data linkage 8-13 years later showed 14 were deceased (3% of cohort), 57% male, median age 28.3 years (24.8-32.9). Acute or chronic diabetes complications accounted for 25% of deaths. In multivariable GEE, elevated AER (OR 4.54, 1.23-16.80, Conclusion: Mortality in young adults with type 1 diabetes is predicted by subclinical markers of autonomic neuropathy and elevated AER during adolescence, but not glycemia. Mortality was over twice that of the background population in females but not in males.

Indexed as

Diabetes Mellitus, Type 1Diabetic AngiopathiesAdolescentAdultAlbuminuriaAustraliaCohort StudiesFemaleHumansLongitudinal StudiesMaleYoung Adult

Identifiers

PMID40302950

DOI10.1155/2024/8194756

PMCPMC12016871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.