Evidence map›Paper›PMID 40302942›Full record

ArticleCyborg and bionic systems (Washington, D.C.)2025

Restoring Somatotopic Sensory Feedback in Lower Limb Amputees through Noninvasive Nerve Stimulation.

Andrea Demofonti, Marco Germanotta, Andrea Zingaro, Gaia Bailo, Sabina Insalaco, Francesca Cordella, Irene Giovanna Aprile, Loredana Zollo

Registry-linked trialAbstract read
In one paragraph

Article in Cyborg and bionic systems (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07448350 (Transcutaneous Electrical Nerve Stimulation for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07448350 narecruitingnot on this mapstarted 2026, after this paper: background citation

Transcutaneous Electrical Nerve Stimulation for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception

TypeinterventionalSponsorCampus Bio-Medico UniversityRan2026 to 2027Enrolled15ConditionsLower Limb Amputation Above Knee, Lower Limb Amputation Below KneeArmsTranscutaneal Electrical Nerve Stimulation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Using EMG Biofeedback to Restore Closed-Loop Neural Control on a Powered Prosthetic Ankle.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea DemofontiResearch Unit of Advanced Robotics and Human-Centred Technologies (CREO Lab), Università Campus Bio-Medico di Roma, 00121 Rome, Italy.ORCID https://orcid.org/0000-0002-8825-486X
Marco GermanottaIRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy.
Andrea ZingaroResearch Unit of Advanced Robotics and Human-Centred Technologies (CREO Lab), Università Campus Bio-Medico di Roma, 00121 Rome, Italy.
Gaia BailoIRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy.
Sabina InsalacoIRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy.
Francesca CordellaResearch Unit of Advanced Robotics and Human-Centred Technologies (CREO Lab), Università Campus Bio-Medico di Roma, 00121 Rome, Italy.
Irene Giovanna AprileIRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy.
Loredana ZolloResearch Unit of Advanced Robotics and Human-Centred Technologies (CREO Lab), Università Campus Bio-Medico di Roma, 00121 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with lower limb amputation experience ambulation disorders since they rely exclusively on visual information in addition to the tactile information they receive from stump-socket interface. The lack of sensory feedback in commercial lower limb prostheses is essential in their abandonment by patients with transtibial amputation (TTA) or transfemoral amputation (TFA). Recent studies have obtained promising results using invasive interfaces with peripheral nervous system presenting drawbacks related to surgery. This paper aims to (a) investigate the potential of transcutaneous electrical nerve stimulation (TENS) as noninvasive means for restoring somatotopic sensory feedback in lower limb amputees and (b) evaluate the effect of the system over a 4-week experimental protocol. The first phase of the study involved 13 participants (6 with TTA and 7 with TFA), and the second one evaluated the long-term effect of TENS on ambulation performance of 2 participants (S1 with TTA and S7 with TFA). The proposed system enhanced participant's ambulation significantly increasing the body weight distribution between legs (S1: from 134% to 143%,

Identifiers

PMID40302942
PMCPMC12038349

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.