ArticleJournal of multidisciplinary healthcare2025
Effects of Various Transfer Strategies of Frozen-Thawed Cleavage-Stage and Blastocyst Embryos on Pregnancy and Neonatal Outcomes in Different Age Groups.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Predictive value of serum β-hCG and blastocyst transfer for clinical pregnancy after frozen-thawed embryo transfer: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Clinical pregnancy, live birth, and twin pregnancy outcomes of nine frozen-thawed embryo transfer strategies across female age groups: a real-world cohort study.Frontiers in endocrinology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study is to assess the impact of different embryo transfer strategies, focusing on cleavage-stage embryos and blastocysts, on pregnancy and neonatal outcomes in frozen-thawed embryo transfer (FET) cycles among women < 35 years old and ≥ 35 years old. Methods: A retrospective cohort analysis of 3,065 FET cycles performed between April 2015 and October 2022 categorized patients into seven groups by embryo morphology, quality, and quantity: single/double high-quality cleavage (A/B), single/double high-quality blastocyst (C/D), single/double poor-quality blastocyst (E/F), and mixed-quality blastocyst (G). Stratified by age (<35/≥35 years), outcomes (clinical pregnancy, live birth, multiple pregnancy, preterm birth) were analyzed using non-parametric tests and chi-square. Results: In women <35 years, transferring two high-quality cleavage embryos (Group B) yielded higher clinical pregnancy (60.12% vs 28.57%) and live birth rates (51.45% vs 19.64%) than single high-quality cleavage embryos (Group A; P < 0.05). For blastocyst transfer, double high-quality blastocysts (Group D) showed higher multiple pregnancy and preterm birth rates than single high-quality blastocysts (Group C; P < 0.05). In women ≥35 years, Group B had superior pregnancy outcomes compared to Group A, while Group D demonstrated significantly higher clinical pregnancy and live birth rates than Group C (P < 0.05). Transferring two poor-quality blastocysts (Group F) improved live birth rates in older patients compared to single poor-quality blastocysts (Group E; 31.91% vs 14.29%, P < 0.05). No significant differences in neonatal birth weight were observed across age groups. Conclusion: For FET cycles, transferring two high-quality cleavage embryos is recommended for all ages. Women <35 years should prioritize single high-quality blastocyst transfer to minimize multiple pregnancies and preterm births, while those ≥35 years benefit from double high-quality blastocysts. Transferring two poor-quality blastocysts may enhance pregnancy outcomes in older patients. These findings warrant validation through multicenter studies to ensure clinical applicability.
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