ArticleFrontiers in public health2025
Association between abdominal obesity and cognitive decline among Chinese middle-aged and older adults: a 10-year follow-up from CHARLS.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between abdominal obesity and cognitive outcomes in middle-aged adults: a systematic review.Frontiers in nutrition · 2026Pooled it
- Nonlinear association of the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio with cognitive function in older Chinese adults: A prospective cohort study.The Journal of international medical research · 2026Article
- A 6-year cohort study of the associations of body mass index, waist circumference, and waist-hip ratio with cognitive impairment in Chinese elderly.Frontiers in psychology · 2026Article
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6 authors.
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Abstract
Introduction: The relationship between abdominal obesity and cognitive decline has controversial results, and the mediating effect of high-density lipoprotein cholesterol (HDL-C) between them remains uncertain. This study aims to explore the association between abdominal obesity and cognitive decline in middle-aged and older adults, including dose-response relationship and age differences, as well as the mediating effect of HDL-C. Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), involving 3,807 participants aged 45 and above from 2010 to 2020. The TICS-10 was used to assess cognitive function, and the group-based trajectory model (GBTM) was used to explore the potential heterogeneity of cognitive changes. Abdominal obesity was measured by baseline waist circumference (WC) and a sequentially adjusted unordered multinomial logistic regression was used to investigate the association between abdominal obesity and cognitive decline in middle-aged and older adults. Restricted cubic spline (RCS) model was adopted to analyze the dose-response relationship between WC and risk of cognitive decline. HDL-C was used as a mediator to examine the potential causal chain between abdominal obesity and cognitive decline. Results: Among the 3,807 participants, a total of 1,631 individuals (42.84%) had abdominal obesity. The GBTM identified 3 cognitive function trajectories: rapid decline (11.0%), slow decline (41.1%) and stable groups (47.9%). After controlling for confounders, participants with abdominal obesity were less likely to experience rapid decline ( Conclusion: Abdominal obesity had a significant protective effect on cognitive decline in Chinese middle-aged and older adults, with HDL-C playing a mediating role in the relationship between abdominal obesity and cognitive decline.
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