Evidence map›Paper›PMID 40302749›Full record

ArticleTransboundary and emerging diseases2025

The H5N6 Virus Containing Internal Genes From H9N2 Exhibits Enhanced Pathogenicity and Transmissibility.

Manlin He, Lina Liu, Jinglei Hu, Zhenjun Wang, Zhendong Guo, Xiaohan Wang, Yongyang Sun, Shaowen Shi, Wenhao Ren, Yuxing Wang and 8 more

Abstract read
In one paragraph

Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Manlin HeChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.ORCID https://orcid.org/0009-0009-9109-6266
Lina LiuChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Jinglei HuChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Zhenjun WangInstitute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130122, China.ORCID https://orcid.org/0000-0001-9774-9074
Zhendong GuoChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Xiaohan WangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Yongyang SunChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Shaowen ShiChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Wenhao RenChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Yuxing WangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Xiaoxuan NieChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.ORCID https://orcid.org/0009-0002-3840-3932
Chao ShangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Zirui LiuChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Qiwei JiangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Zilin RenChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Ningyi JinChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.
Xiao LiChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.ORCID https://orcid.org/0009-0004-0765-475X
Zongzheng ZhaoChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.ORCID https://orcid.org/0000-0003-0040-7452

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The H5N6 avian influenza virus (AIV) is constantly undergoing recombination and evolution with other subtypes of AIV, resulting in various types of recombinant H5N6 viruses. However, the risk to human public health of different recombinant types of H5N6 viruses remains unclear. Recently, two types of different recombinant H5N6 viruses were isolated from chickens. One of the viruses possessed six internal genes originating from H9N2, named A/Chicken/Hubei/112/2020 (H5N6) (abbreviated 112); the other virus possessed PB2, PB1, PA, and NP originating from H5N1, while the M and NS genes were derived from H9N2, named A/Chicken/Hubei/125/2020 (H5N6) (abbreviated 125). Here, we investigated the receptor binding properties, pathogenicity, and transmissibility of the two H5N6 AIVs. The results showed that 112 and 125 could bind

Indexed as

Influenza A virusInfluenza A Virus, H9N2 SubtypeInfluenza in BirdsOrthomyxoviridae InfectionsAnimalsChickensFemaleHumansInfluenza A Virus, H5N6 SubtypeMiceMice, Inbred BALB CVirulence

Identifiers

PMID40302749
PMCPMC12017012

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.