ArticleJournal of cosmetic dermatology2025
Efficacy and Safety of Long-Term Azathioprine Therapy for Severe Alopecia Areata: A 10-Year Cohort Study.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Real World Evidence in Alopecia Areata: Current Management, Emerging Therapies and Future Challenges - A Narrative Review.Journal of inflammation research · 2026Review
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Authors and funding
2 authors.
Funding
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Abstract
backgroundAlopecia areata is an autoimmune disease in which T cells may play a key role in its pathogenesis. Various immunosuppressive drugs have been employed with varying degrees of success.
objectivesThis study aimed to evaluate the long-term efficacy and safety of azathioprine as a systemic monotherapy for moderate to severe alopecia areata.
methodsA total of 63 patients (27 females [42.9%] and 36 males [57.1%]) with a minimum 6-month history of alopecia areata were included. The extent of scalp hair regrowth was assessed during the treatment and annually for up to 10 years using the Severity of Alopecia Tool (SALT score). The primary endpoint was the percent change in SALT score during treatment. The daily dosage of azathioprine was calculated at 2 mg/kg of body weight.
resultsThe mean duration of the current episode of scalp hair loss was 34.10 months (±39.16). The mean percentage of hair regrowth was 92.69% (±9.08). The mean percentage of hair loss decreased from 74.2% (±27.8) before treatment to 5.2% (±8.6) after 10 years of azathioprine treatment, indicating a highly significant statistical improvement (Paired t-test, 95% CI = 55.9-75.3). The mean hair loss score (S0-S5) improved from 5.56 (±1.3) before treatment to 0.67 (±0.53) after 10 years of treatment, showing a significant difference from the baseline score (Wilcoxon signed-rank test, p < 0.0001).
conclusionThis study demonstrates that azathioprine is a safe and effective systemic therapy for the treatment of recalcitrant and severe alopecia areata.
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