ArticleActa oncologica (Stockholm, Sweden)2025
Mental illness and non-metastatic colorectal cancer treatment and survival, a nationwide study of almost 70,000 patients.
Article in Acta oncologica (Stockholm, Sweden), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact of Schizophrenia Spectrum Disorders on the Receipt of Invasive and Systemic Therapy for Colorectal Cancer: A Nationwide Multicenter Retrospective Cohort Study in Japan.Acta psychiatrica Scandinavica · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe impact of mental illness on treatment and outcomes for patients with colorectal cancer (CRC) has not been investigated with potential confounders and mediators accounted for. PATIENTS AND
methodsColorectal Cancer Database (CRCBaSe), a linked national registry database, was used to analyse stage I-III CRC patients diagnosed in Sweden between 2008 and 2021. The exposure of interest was a history of mental illness. Treatment outcomes were analysed with logistic regressions. Flexible parametric models were fitted for survival analysis. Analyses were adjusted for pre-specified confounders.
resultsPatients with a history of severe mental illness presented with more advanced tumours and comorbidities. They were more likely to undergo emergency surgery (OR 1.56, 95% CI 1.32-1.84) and less likely to receive adjuvant treatment (OR 0.65, 95% CI 0.53-0.80) than patients with no history of mental illness. Five-year standardised overall survival (OS) was worse for those with a history of mild and severe mental illness, 64.6% (95%CI 63.9-65.3) and 61.8% (95%CI 59.7-63.8) compared to those without 69.3% (95%CI 68.9-69.7). Although time to recurrence was not significantly impacted, standardised survival after recurrence was worse for patients with a history of severe mental illness, with a 3-year survival after recurrence of 24% compared to 30% in those without a history of mental illness.
interpretationAlthough the differences were smaller compared to previous studies, patients with a history of mental illnesses still do worse. The management of CRC patients with psychiatric comorbidities presents complex challenges necessitating personalised solutions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.