Evidence map›Paper›PMID 40302620›Full record

ArticleACS chemical neuroscience2025

Zinc-Dependent Modulation of Dopamine Release and Uptake Is Altered in Parkinson's Disease Model Zebrafish.

Piyanka Hettiarachchi, Austin Shigemoto, Erin E Hickey, Shawn C Burdette, Michael A Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Piyanka HettiarachchiDepartment of Chemistry and R.N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0001-6678-810X
Austin ShigemotoDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States.
Erin E HickeyDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States.
Shawn C BurdetteDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, United States.ORCID 0000-0002-2176-0776
Michael A JohnsonDepartment of Chemistry and R.N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0001-5078-9896

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HOLMSTROM, ERIK D · 2012 to 2021
$22.1M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Susan M Lunte · 2022 to 2026
$6.9M
Tools for neuronal pathway analysis at sub-second and single-cell resolutionR21NS109659 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI JOHNSON, MICHAEL A. · 2018 to 2019
$406k
NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P30 GM145499NINDS NIH HHS R21 NS109659
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative movement disorder in which dopaminergic neurons progressively degenerate, resulting in impaired dopamine system function. The release and uptake of dopamine (DA) are modulated, in part, by free, ionic zinc (Zn

Indexed as

BrainDopamineParkinson DiseaseZincAnimalsDisease Models, AnimalRotenoneZebrafishDopamineRotenoneZinccaged compoundParkinson’s diseaserotenonevoltammetryzinc

Identifiers

PMID40302620
PMCPMC12096094

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.