Evidence map›Paper›PMID 40302608›Full record

ArticleACS applied materials & interfaces2025

Efficient Direct Cytosolic Protein Delivery via Protein-Linker Co-engineering.

Lixia Wei, Heyun Wang, Melis Özkan, Andrada-Ioana Damian-Buda, Colleen N Loynachan, Suiyang Liao, Francesco Stellacci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lixia WeiInstitute of Materials Science and Engineering, École polytechnique fédérale de Lausanne, Lausanne 1015, Switzerland.
Heyun WangInstitute of Materials Science and Engineering, École polytechnique fédérale de Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0001-6764-4220
Melis ÖzkanInstitute of Materials Science and Engineering, École polytechnique fédérale de Lausanne, Lausanne 1015, Switzerland.
Andrada-Ioana Damian-BudaInstitute of Biomaterials, Department Materials Science and Engineering, Friedrich-Alexander-Universität, Erlangen 91054, Germany.
Colleen N LoynachanInstitute of Materials Science and Engineering, École polytechnique fédérale de Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0001-5617-4091
Suiyang LiaoInstitute of Materials Science and Engineering, École polytechnique fédérale de Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0003-0705-9112
Francesco StellacciInstitute of Materials Science and Engineering, École polytechnique fédérale de Lausanne, Lausanne 1015, Switzerland.ORCID 0000-0003-4635-6080

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein therapeutics have enormous potential for transforming the treatment of intracellular cell disorders, such as genetic disorders and cancers. Due to proteins' cell-membrane impermeability, protein-based drugs against intracellular targets require efficient cytosolic delivery strategies; however, none of the current approaches are optimal. Here, we present a simple approach to render proteins membrane-permeable. We use arginine-mimicking ligand

Indexed as

CytosolProtein EngineeringAnimalsApoptosisCattleCytochromes cHumansOvalbuminSerum Albumin, BovineCytochromes cOvalbuminSerum Albumin, Bovinearginine-mimicking ligandcell penetrationcytosolic deliverymembrane permeabilityprotein functionalizationprotein therapeutics

Identifiers

PMID40302608
PMCPMC12086766

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.