Evidence map›Paper›PMID 40302518›Full record

ArticleJournal of the Royal Society, Interface2025

Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure.

Valentina Buonfiglio, Niccolò Zagli, Irene Pertici, Vincenzo Lombardi, Pasquale Bianco, Duccio Fanelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Valentina BuonfiglioPhysioLab, University of Florence, Sesto Fiorentino (FI), Italy.ORCID 0000-0003-1528-2955
Niccolò ZagliNORDITA, Stockholm University and KTH Royal Institute of Technology, Stockholm, Sweden.
Irene PerticiPhysioLab, University of Florence, Sesto Fiorentino (FI), Italy.
Vincenzo LombardiPhysioLab, University of Florence, Sesto Fiorentino (FI), Italy.
Pasquale BiancoPhysioLab, University of Florence, Sesto Fiorentino (FI), Italy.
Duccio FanelliDepartment of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy.

Funding

European Joint Program on Rare Diseases 2019, PredACTINgWallenberg Initiative on Networks and Quantum Information
6 · The paper itself

Abstract

A data fitting procedure is devised and thoroughly tested to provide self-consistent estimates of the relevant mechanokinetic parameters involved in a plausible scheme underpinning the output of an ensemble of myosin II molecular motors mimicking the contraction of skeletal muscle. The method builds on a stochastic model accounting for the force exerted by the motor ensemble operated both in the low and high force-generating regimes corresponding to different temperature ranges. The proposed interpretative framework is successfully challenged against simulated data, meant to mimic the experimental output of a one-dimensional synthetic nanomachine powered by pure muscle myosin isoforms.

Indexed as

Models, BiologicalMuscle, SkeletalMyosinsMyosin Type IIAnimalsKineticsTemperatureMyosinsMyosin Type IImusclemyosinmyosin-based synthetic machinestochastic population dynamics

Identifiers

PMID40302518
PMCPMC12041895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.