ArticleRenal failure2025
Bidirectional Mendelian Randomization analysis of iron status and uremia: no evidence of a causal relationship.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Iron status and uremia have been linked, but the causality remains ambiguous. This bidirectional study aimed to explore the causal association between genetically predicted iron status and uremia. Utilizing summary data from genome-wide association studies (GWAS) of iron status and uremia, a two-sample Mendelian Randomization (MR) design was employed. Iron status was assessed through serum iron (SI), serum ferritin (SF), total iron-binding capacity (TIBC), and transferrin saturation (TS), while uremia included renal failure and dialysis. The primary analysis was conducted using the Inverse Variance Weighted (IVW) method. Additional MR evaluation included the weighted median, weighted mode, simple mode, and MR-Egger regression methods. Sensitivity analysis included MR-Egger for pleiotropy, MR-PRESSO for detecting outliers, Cochran's Q test for heterogeneity, and leave-one-out analysis for robustness. Genetically determined iron status did not have a causal effect on the risk of uremia (renal failure or dialysis). The primary IVW results indicated no statistically significant relationship between iron status and uremia (all
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