ArticleThe Journal of clinical endocrinology and metabolism2025
Regional Brain Structure Alterations in Diabetes but Not Prediabetes.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Regional Brain Structure Alterations in Diabetes but Not Prediabetes.The Journal of clinical endocrinology and metabolism · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextDiabetes (DM) affects brain volume and white matter hyperintensity (WMH), but whether regional gray matter volume (GMV) and tract-specific WMH progress in the prediabetes (PreDM) stage remains unclear.
objectiveWe investigate brain structural changes across 3 distinct glycemic states.
methodsWe analyzed 512 participants (122 with DM, 109 with PreDM, and 281 controls) using advanced neuroimaging techniques. High-resolution structural T1-weighted magnetic resonance images and FLAIR (fluid-attenuated inversion recovery) images were acquired, complemented by cognitive assessments, grip strength measurements, and gait speed testing. We performed correlational analyses to examine the relationships between observed brain changes, cognitive performance, and motor function across different levels of glycemic states.
resultsWe found substantial changes in GMV in DM, especially in areas responsible for movement and coordination, including the bilateral cerebellum, right precentral gyrus, and left postcentral gyrus (P < .001 uncorrected with cluster size > 500). These brain changes were associated with decreases in cognitive test scores (Montreal Cognitive Assessment; P = .04), gait speed (P < .05), and right-hand grip strength (P < .05)-effects not seen in the prediabetic group. We observed significantly higher WMH index across 20 tracts in DM brains (P < .05; false discovery rate [FDR]-corrected). Glycemic levels positively correlated with WMH index in multiple tracts (P < .05; FDR-corrected).
conclusionThis study illuminates DM as a powerful force in cerebral architecture, challenging the notion of a gradual decline beginning in PreDM. These insights not only underscore the critical importance of DM prevention but also hint at the brain's remarkable resilience in the face of early metabolic challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.