Evidence map›Paper›PMID 40302121›Full record

ArticleAnalytical chemistry2025

Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy.

Elina A Harju, Teemu Tomberg, Lea Wurr, Anneleen van Rijckeghem, Alba M Arbiol Enguita, Vladimir Dordovic, Niklas G Johansson, Heikki Räikkönen, Antti Isomäki, Jukka K S Saarinen and 3 more

Abstract read
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In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elina A HarjuDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.ORCID 0009-0009-3464-844X
Teemu TombergDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0003-3448-2880
Lea WurrDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.
Anneleen van RijckeghemDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.
Alba M Arbiol EnguitaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.ORCID 0009-0009-8721-4100
Vladimir DordovicZentiva, k.s., U.K.abelovny 130, Prague 10 10237, Czech Republic.
Niklas G JohanssonDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-8226-4813
Heikki RäikkönenDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.
Antti IsomäkiBiomedicum Imaging Unit, University of Helsinki, Helsinki 00014, Finland.
Jukka K S SaarinenDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0002-5699-4054
Keith C GordonDodd-Walls Centre for Photonic and Quantum Technologies and Department of Chemistry, University of Otago, Dunedin 9054, New Zealand.ORCID 0000-0003-2833-6166
Bert van VeenOrion Corporation, Espoo 02200, Finland.
Clare J StrachanDrug Research Program, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0003-3134-8918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we employed stimulated Raman scattering (SRS) microscopy, augmented with sum frequency generation, to characterize complex solid-state mixtures, containing many solid-state forms of the same compound, for the first time. Five crystalline forms and one amorphous form of lactose were characterized and resolved, including two more recently defined anhydrous solid-state forms. Additionally, the complex solid-state character of several commercially available pharmaceutical tableting and inhalation grades of lactose was profiled. The advanced multimodal label-free microscopy method enabled visualization of the distribution of the solid-state forms with submicron spatial resolution, including the detection of trace levels. In addition, quantitative solid-state compositions of the lactose products were estimated. Overall SRS microscopy allows sensitive and specific spatially resolved solid-state characterization of complex mixtures, beyond what is possible with established (nonspatially resolved) characterization methods.

Indexed as

LactoseNonlinear Optical MicroscopySpectrum Analysis, RamanMicroscopyPharmaceutical PreparationsTabletsLactosePharmaceutical PreparationsTablets

Identifiers

PMID40302121
PMCPMC12079631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.