Evidence map›Paper›PMID 40302114›Full record

ArticlePrenatal diagnosis2025

Fetal Endoscopic Tracheal Occlusion (FETO) for Left and Right Congenital Diaphragmatic Hernia in Canada.

Yada Kunpalin, Anna Otvodenko, Tim Van Mieghem, Priscilla P L Chiu, Paolo Campisi, Shiri Shinar, Prakesh S Shah, Christina Marrata, Dilkash Kajal, Greg Ryan and 1 more

Abstract read
In one paragraph

Article in Prenatal diagnosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yada KunpalinDepartment of Obstetrics & Gynaecology, Ontario Fetal Centre, Mount Sinai Hospital, Toronto, Canada.ORCID 0000-0002-7388-1414
Anna OtvodenkoDepartment of Obstetrics & Gynaecology, Ontario Fetal Centre, Mount Sinai Hospital, Toronto, Canada.
Tim Van MieghemDepartment of Obstetrics & Gynaecology, Ontario Fetal Centre, Mount Sinai Hospital, Toronto, Canada.ORCID 0000-0002-3034-6905
Priscilla P L ChiuUniversity of Toronto, Toronto, Canada.
Paolo CampisiUniversity of Toronto, Toronto, Canada.
Shiri ShinarDepartment of Obstetrics & Gynaecology, Ontario Fetal Centre, Mount Sinai Hospital, Toronto, Canada.ORCID 0000-0001-6352-4846
Prakesh S ShahUniversity of Toronto, Toronto, Canada.
Christina MarrataUniversity of Toronto, Toronto, Canada.
Dilkash KajalUniversity of Toronto, Toronto, Canada.
Greg RyanDepartment of Obstetrics & Gynaecology, Ontario Fetal Centre, Mount Sinai Hospital, Toronto, Canada.
Nimrah AbbasiDepartment of Obstetrics & Gynaecology, Ontario Fetal Centre, Mount Sinai Hospital, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe perinatal and short-term pediatric outcomes and procedural safety of fetal endoscopic tracheal occlusion (FETO) in a Canadian national referral centre.

methodsRetrospective study including all consecutive FETO cases at the Ontario Fetal Centre between 2010 and 2024. Maternal and fetal baseline characteristics, technical aspects and short-term outcomes until 6 months are described.

resultsFETO was successfully performed in 47/48 (98%) cases at an average gestational age (GA) of 28.5 (24-31.6) weeks including 22 (47%) moderate LCDH (M-LCDH), 12 (25%) severe LCDH (S-LCDH) and 13 (28%) right CDH (RCDH). There were no major complications. Balloon removals were emergent in 23/46 (50%) and challenging in 14/46 (30%) of cases. Preterm premature rupture of membranes (< 37 weeks) occurred in 70% (33/47) with average GA at birth of 35.9 weeks (29.0-40.4 weeks). Survival to discharge was 54% (25/46), specifically 64% (14/22), 33% (4/12), and 58% (7/12) among M-LCDH, S-LCDH and RCDH, respectively. Patch repair was performed in 28/30 (93%). Supplemental oxygen and tube feeding were required in 32% (8/25) and 68% (15/22) of survivors at discharge, respectively.

conclusionsIn this North American series, FETO outcomes were similar to those observed in international trials, confirming its effectiveness. Studies are ongoing to evaluate long-term outcomes.

Indexed as

Balloon OcclusionFetoscopyHernias, Diaphragmatic, CongenitalTracheaAdultCanadaFemaleGestational AgeHumansInfant, NewbornOntarioPregnancyRetrospective StudiesTreatment OutcomeCDHcongenital diaphragmatic herniafetal surgeryfetal therapyfetoscopyprenataltracheal occlusionultrasound

Identifiers

PMID40302114
PMCPMC12137032

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.