ArticleAsian Pacific journal of cancer prevention : APJCP2025
Antioxidant and Apoptotic Activity of Curcumin Nanoparticles on HEp-2 Cell Line.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Ameliorative effects of curcumin and resveratrol following abamectin-induced liver injury in rats.Scientific reports · 2026Article
- An assessment of curcumin, curcumin spanlastics nanoparticles, and curcumin nanocrystals as possible drug delivery systems with antimicrobial, antioxidant, and antitumor activities.BMC biotechnology · 2026Article
- Curcumin treatment attenuates methotrexate-induced nephrotoxicity in rats by inhibiting inflammation and fibrosis.Journal of molecular histology · 2026Article
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Authors and funding
2 authors.
Funding
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Abstract
introductionNanocurcumin is a widely used anti-inflammatory agent due to its antioxidant and anti-inflammatory properties. AIM OF THE STUDY: The current study aimed to examine cytotoxicity, antioxidant and apoptotic Activity of Curcumin nanoparticles on squamous cell carcinoma (HEp-2). MATERIAL AND
methodsThe present work conducted to evaluate the cytotoxicity using MTT assay, evaluation of morphological changes post cell treatment with Curcumin nanoparticles, also evaluation of cell apoptosis using Annexin V-FITC and Propidium Iodide (PI) staining. Finally, Genotoxicity was traced via arranging for flow cytometry.
resultsData recorded revealed that the inhibitory concentration (IC50) of Curcumin nanoparticles was 40.82 ug/ ml. Also, cytotoxicity was concentration dependent with significant difference (p<0.05). Cytotoxicity enhanced apoptosis process accompanied with cell cycle arrest through the induction of G2/M and pre-G1 phases arrest compared with that of control cell. Cytotoxicity accompanied with morphological changes denoting apoptosis and necrosis after treatment with Curcumin nanoparticles. In the meantime, the biochemical marker (ROS) was elevated in a significant way post treatment with Curcumin nanoparticles.
conclusionNanocurcumin has a potent anticancer effect due to its antioxidant and anticancer activity.
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