Evidence map›Paper›PMID 40302079›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Evaluation of Therapeutic Activity of Tualang Honey on Oral Cancer: Histopathological Study.

May Al-Koshab, Rola Ali-Saeed, Aied Mohammed Alabsi, Siddig Ibrahim Abdelwahab, Meram Azzani, Muhamad Fareez Ismail, Maged A Al-Garadi, Vetriselvan Subramaniyan

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

May Al-KoshabDepartment of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Rola Ali-SaeedDepartment of Preclinical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Aied Mohammed AlabsiDepartment of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Siddig Ibrahim AbdelwahabHealth Research Centre, Jazan University, Jazan, Saudi Arabia.
Meram AzzaniDepartment of Public Health Medicine, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia.
Muhamad Fareez IsmailSchool of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia.
Maged A Al-GaradiAnimal Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Vetriselvan SubramaniyanDepartment of Medical Sciences, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe use of natural products has been gaining interest, notably, in the area of cancer therapy. In this study, we determined the chemotherapeutic activity of Tualang Honey (TH) Malaysian wild local honey, on an animal model induced for oral cancer using 4NQO.

methodsA total of 28 male Sprague-Dawley (SD) rats were randomized into four groups (n=7 per group) as non-treated, treated (1000 mg/kg) 1000, treated 2000 mg/kg and control group. All groups' rats received 4NQO, followed by 10 weeks administration of TH at 1000 and 2000 mg/kg, respectively, for the treated groups.  All rats from all experiments were sacrificed to evaluate the incidence of oral neoplasms with histopathological changes and histological evaluation of oral cancer metastasis.

resultsTH significantly reduced the incidence of SCC from 100% to 28.6 % in the TH high dose group of 2000 mg/kg. furthermore, TH has the ability to inhibit the metastasis of oral cancer to adjacent organs.

conclusionTH inhibited the proliferation of the cancer cells in an animal model of oral squamous cell carcinoma and therefore, has the potential to be developed as a chemotherapeutic agent.

Indexed as

Carcinoma, Squamous CellHoneyMouth Neoplasms4-Nitroquinoline-1-oxideAnimalsCell ProliferationDisease Models, AnimalMaleRatsRats, Sprague-Dawley4-Nitroquinoline-1-oxide4-nitroquinoline 1-oxideChemotherapeuticoral squamous cell carcinomaTualang Honey

Identifiers

PMID40302079
PMCPMC12227949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.