Evidence map›Paper›PMID 40302074›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

The Role of Oral Microbiota in the Development of Oral Squamous Cell Carcinoma Using MicroRNA and Apoptosis-Related Gene Expression: An Exploratory Study.

Abdolreza Mohamadnia, Mohammad Bayat, Melika Norouzi, Zahra Gharayagh Zandi, Fereshteh Shirzadian, Mehdi Kazempoor Dizaji, Mohamad Hosein Soltani, Seyedeh Zahra Fotook Kiaei, Mohammad Varahram, Farnaz Ahmadi and 2 more

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abdolreza MohamadniaChronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad BayatCraniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Melika NorouziDepartment of Microbiology, College of Biology, Tehran North branch, Islamic, Tehran, Iran.
Zahra Gharayagh ZandiDepartment of Microbiology, College of Biology, Tehran North branch, Islamic, Tehran, Iran.
Fereshteh ShirzadianDepartment of Microbiology, College of Biology, Tehran North branch, Islamic, Tehran, Iran.
Mehdi Kazempoor DizajiMycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohamad Hosein SoltaniDepartment of Biology, Faculty of Sciences, Islamic Azad University, Tehran, Iran.
Seyedeh Zahra Fotook KiaeiDepartment of Pulmonary and Critical Care, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad VarahramMycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farnaz AhmadiLung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shadi ShafaghiLung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Naghmeh BahramiCraniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-3575-4094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveOral cancer is one of the malignant tumors of the head and neck region, which is associated with high mortality rates and has various negative effects on the aesthetics of patients. Therefore, access to high-quality care for early detection and appropriate surgical and drug treatments is crucial. To this end, researchers are investigating the mechanisms of carcinogenesis in cells and identifying the factors that affect it. The aim of this study was to investigate the mechanisms by which oral microbiota contributes to carcinogenesis. MATERIALS AND

methodsSixty peripheral blood samples were collected from oral squamous cell carcinoma (OSCC) patients with (30 samples) and without (30 samples) of oral infection, referred to the Cancer Institute of Tehran University of Medical Sciences. Real-time PCR was performed to determine the expression levels of miR-92, miR-26, miR-486, Bak, Bax, and Caspase-8 genes.

resultsMiR-92 and miR-26 relative expression were higher in the OSCC patients with oral infection compared to OSCC patients without oral infection. However, relative expression of miR-486, Bak, Bax, and Caspase-8 was significantly decreased in patients with oral infection compared to OSCC patients without oral infection.  Conclusion: The results showed that oral microbiome prevents apoptosis and promotes the development of cancerous tissue in OSCC patients. The identification of a link between oral infection and microRNA and apoptosis-related gene expression could provide researchers with the opportunity to formulate innovative methods for the prevention or management of OSCC.

Indexed as

ApoptosisCarcinoma, Squamous CellMicrobiotaMicroRNAsMouthMouth NeoplasmsAdultAgedBiomarkers, TumorCase-Control StudiesFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansMaleMiddle AgedBiomarkers, TumorMicroRNAsMIRN92 microRNA, humanApoptosis-related genesMicroRNAOral Microbiomeoral squamous cell carcinoma

Identifiers

PMID40302074
PMCPMC12227961

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