SynthesisAsian Pacific journal of cancer prevention : APJCP2025
Diagnostic Accuracy of DNA Ploidy for Oral Potentially Malignant Disorders: A Systematic Review and Meta Analysis.
Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveto compare the diagnostic accuracy of DNA ploidy compared to biopsy followed by histopathological investigation in patients with oral potentially malignant disorders (OPMDs).
methodThe review protocol is registered under PROSPERO(CRD42024524656) and performed in accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis - Diagnostic Test Accuracy (PRISMA- DTA) checklist. Databases like PubMed, Google Scholar, EBSCOhost were searched from 2000 to 2024 to identify the diagnostic potential of DNA ploidy for various OPMDs. True-positive, false-positive, true-negative, false-negative, sensitivity, specificity values were calculated manually if not present for each study. Quality assessment of included studies was evaluated based on Quality assessment of diagnostic accuracy studies (QUADAS)- 2 tool using review manager (RevMan ver. 5.3). Meta-analysis was performed in Meta-Disc 1.4 software for pooled sensitivity and specificity. Additional analysis was performed in terms of positive likelihood ratio (+LR), negative likelihood ratio (-LR), diagnostic odds ratio (DOR) and summary receiver operating characteristics (SROC) with Area Under Curve (AUC) and p<0.05 as statistically significant.
resultsNine studies were included for qualitative synthesis and seven studies for meta-analysis. Included studies reported low risk of bias (ROB). Various OPMDs (oral leukoplakia (OL), oral lichen planus (OLP), erythroplakia (OE), oral erythro-leukoplakia and other oral dysplastic lesions were evaluated. The meta-analysis revealed an overall pooled sensitivity of 0.71 (CI 0.28- 0.96) and pooled specificity of 0.31 (CI 0.03- 0.79) with +PLR 0.99 (0.49 - 2.02) and -NLR 0.99 (0.18 - 5.48) and a DOR of 1.05 (0.07 - 16.14) with an overall diagnostic accuracy (AUC) of 0.49.
conclusionThis study findings provide evidence on ability of DNA ploidy for various OPMDs for early screening and diagnosis. DNA ploidy can be taken for secondary level of prevention for OPMD under early diagnosis and prompt treatment.
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