Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional study.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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5 · Who and what money
Authors and funding
16 authors.
Giuseppe Lisco *Interdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", Bari, Italy. giuseppe.lisco@uniba.it.ORCID 0000-0001-6521-8578
Davide Guido *Unit of Data Science, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, Bari, 70013, Italy.ORCID 0000-0002-3291-3686
Nicole CerabinoCenter of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, 70013, Bari, Italy.ORCID 0009-0009-8524-3709
Martina Di ChitoCenter of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, 70013, Bari, Italy.ORCID 0009-0007-2759-8347
Rosanna DonvitoCenter of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, 70013, Bari, Italy.
Caterina BonfiglioUnit of Data Science, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, Bari, 70013, Italy.ORCID 0000-0002-8650-348X
Endrit ShahiniDepartment of Gastroenterology, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, 70013, Bari, Italy.ORCID 0000-0002-4909-0436
Marianna ZappimbulsoDepartment of Gastroenterology, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, 70013, Bari, Italy.
Cristiana RandazzoDipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), Materno-Infantile, University of Palermo, Palermo, Italy.ORCID 0000-0001-9081-6190
Domenico BarlettaLaboratory of Clinical Pathology, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, 70013, Bari, Italy.
Dolores StabileCore Facility Biobank, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, Bari, 70013, Italy.ORCID 0009-0000-0259-9799
Anna AnconaCore Facility Biobank, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, Bari, 70013, Italy.ORCID 0009-0009-7662-1763
Sergio ColettaCore Facility Biobank, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, Bari, 70013, Italy.
Pasqua Letizia PesoleCore Facility Biobank, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, Bari, 70013, Italy.ORCID 0000-0003-4675-2075
Gianluigi GiannelliScientific Direction, National Institute of Gastroenterology "Saverio de Bellis", IRCCS Hospital, Castellana Grotte, 70013, Bari, Italy.ORCID 0000-0002-5140-8060
Giovanni De PergolaCenter of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, 70013, Bari, Italy.ORCID 0000-0003-0020-3273
Funding
Ministero della Salute Ricerca Corrente 2024-2026
6 · The paper itself
Abstract
backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of steatotic liver disease and has major implications on cardiovascular safety. STUDY
aimsAs the precise role linking MASLD to cardiovascular diseases is still unclear, the present study aims to investigate the association between liver steatosis and fibrosis and circulating plasminogen activator inhibitor-1 (PAI-1) levels.
methodsEighty-two patients (41.6 ± 12.4 yrs, 34 men, 41%), naïve to medications, who attended the Nutrition Center for the Research and Care of Obesity and Metabolic Diseases at the National Institute of Gastroenterology "Saverio de Bellis" for weight management, were cross-sectionally evaluated. Demographic, anthropometric, clinic, and laboratory data were collected and analyzed. All patients underwent liver ultrasonographic assessment by FibroScan to diagnose liver steatosis (controlled attenuation parameter or CAP > 275 dBm) and fibrosis (liver stiffness > 8.2 kPa).
resultsSixty-one individuals (74.4%) had liver steatosis, and 17 (20.7%) had liver fibrosis. PAI-1 mean levels were 3,261 ± 1,270 pg/mL, mean body mass index (BMI) and waist circumference (WC) values were 36.6 ± 7.1 kg/m DISCUSSION: Circulating PAI-1 levels are correlated with liver steatosis and, to a lesser extent, fibrosis in apparently healthy patients with a BMI ≥ 25 kg/m
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional study. · full record | OpenQuestion