Evidence map›Paper›PMID 40301903›Full record

ReviewCancer cell international2025

Progress of mesenchymal stem cell-derived exosomes in targeted delivery of antitumor drugs.

Defa Huang, Wenlong Huang, Meijin Liu, Jie Chen, Dewang Xiao, Zongbo Peng, Haoquan He, Haibin Shen, Qing Jin, Linli Chen and 3 more

Abstract readReview
In one paragraph

Review in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Defa Huang *Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Wenlong Huang *Department of General Medicine, First People's Hospital of Zunyi (Third Affiliated Hospital of Zunyi Medical University), Zunyi, 563000, China.
Meijin Liu *People's Hospital of Ganzhou Economic Development Zone, Ganzhou, 341000, China.
Jie ChenDepartment of Laboratory Medicine, the Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, 402177, China.
Dewang XiaoThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, China.
Zongbo PengThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, 341000, China.
Haoquan HeDepartment of General Practice, Ditian Community health centre, Jinhua jindong, xiaoshun, 321000, China.
Haibin ShenLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Qing JinLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Linli ChenLaboratory Medicine, Guizhou Aerospace Hospital, Zunyi, 563100, China.
Dingyu RaoDepartment of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China. 18329037521@163.com.
Minghong ZhaoLaboratory Medicine, Guizhou Aerospace Hospital, Zunyi, 563100, China. minghong21@163.com.
Junyun HuangLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China. 13879789666@163.com.

Funding

Jiangxi Province Administration of Traditional Chinese Medicine Scienceand Technology Plan Project 2024B0303Jiangxi Provincial Health Commission Technology Plan Project 202510463the Ganzhou Science and Technology Plan Project 2023LNS37081 and GZ2024YLJ137
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are currently being used in clinical trials for the treatment of a wide range of diseases and have a wide range of applications in the fields of tissue engineering and regeneration. Exosomes are extracellular vesicles containing a variety of components such as proteins, nucleic acids and lipids, which are widely present in biological fluids and have the functions of participating in intercellular information transfer, immune response and tissue repair, and can also be used as carriers to target and deliver tumors to improve therapeutic effects. Mesenchymal stem cell-derived Exosomes (MSC-Exos), which have the advantages of low immunogenicity and high tumor homing ability, have attracted much attention in targeted drug delivery. Here, we review the current knowledge on the involvement of MSC-Exos in tumor progression and their potential as drug delivery systems in targeted therapies. It also discusses the advantages and prospects of MSC-Exos as a drug carrier and the challenges that still need to be overcome.

Indexed as

Drug deliveryExosomesMesenchymal stem cellsTargeted tumor therapyTumor

Identifiers

PMID40301903
PMCPMC12042352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.