ArticleJournal of nanobiotechnology2025
Ferrocene-derived magnetic fiber-particles from diesel exhaust: enhanced pulmonary toxicity via Bach1-SAT1-polyamine depletion.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Blue mussel (Mytilus edulis) lipid extract prevents metabolic dysfunction-associated steatotic liver disease.Journal of the science of food and agriculture · 2026Article
- Melatonin modulates SHH/GLI3 signaling and placental angiogenesis to counter acrylamide embryotoxicity.Journal of molecular histology · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
aimMagnetic nanoparticles are key components of air pollution. The combustion of diesel engine fuels, especially with ferrocene doping to reduce emissions, may increase exposure to these particles and related health risks. This study aimed to reveal the generation and characterization of ferrocene-derived magnetic particles (FMP) in ferrocene-doped diesel exhaust, and to investigate its toxicities and associated mechanisms in an avian model.
methodsFMP was observed in ferrocene-doped diesel exhaust particles, and extracted with neodymium magnets. Extracted FMP was characterized, and exposed to hatchling chickens via aerosol inhalation. Pulmonary toxicities were assessed with pathological and molecular methods. Associated mechanisms were investigated with RNA-seq, in vitro cell culture, and in vivo gene silencing.
resultsFMP was characterized to be fibrous, magnetic iron-containing carbon particles. Extracted FMP could directly induce pulmonary toxicity. Mechanistic investigations revealed molecular mechanism associated with ferroptosis via Bach1, SAT1 and polyamines depletion, and further confirmed with ferroptosis inhibitor treatment, Bach1 inhibitor treatment, supplementation of polyamines or SAT1 silencing.
conclusionsFerrocene doping could result in formation of magnetic particles in diesel exhaust. For the first time, magnetic fiber-like particles were extracted from ferrocene-doped DE particles, which is a potential source of magnetic particles in air pollution. To better balance emission control and health effects, further investigations are necessary.
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