ArticleBMC veterinary research2025
Untargeted metabolomics analysis of the spleens of ducks infected with Clostridium perfringens type A.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Impact of GAstV-2 infection on intestinal microbiota and renal gene transcriptome in goslings.Poultry science · 2026Article
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5 authors.
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Abstract
backgroundThe aim of this study was to investigate the metabolomic changes in the spleens of ducks artificially infected with Clostridium perfringens type A. Twenty-four healthy ducks aged 1 d were used for this purpose. After acclimatization for 37 d, the ducks were divided into 4 treatment groups (n = 6): the control group (normal group), infection Group 1 (66 h), infection Group 2 (90 h) and infection Group 3 (114 h). The ducks in the corresponding infection group were challenged with 8 mL of C. perfringens type A bacterial solution (1 × 10
resultsAt necropsy, the pathological changes in C. perfringens type A infection included enlarged, haemorrhagic and mottled spleens. Histopathology examination revealed that the ducks in the infection group had damaged spleen tissue structures, dilated spleen sinuses with congestion and bleeding, an extreme decrease in lymphocytes, and massive inflammatory cell infiltration in the splenic tissue. Spleen lesions were observed and PCR tests were positive in ducks in the infection group, indicating that a model of C. perfringens type A infection was successfully established in this study. Compared with those in the normal group, 14, 15 and 20 differentially abundant metabolites were identified after 66, 90 and 114 h, respectively, of C. perfringens type A infection of duck spleens, mainly including indolin-2-one, 3-methylindole, 4-hydroxy-2-quinolinecarboxylic acid, indole-3-methyl acetate, uric acid, 2'-deoxyinosine, urate, xanthine, 3-succinoylpyridine, nicotinic acid, phenylacetylglycine, histamine and phosphoenolpyruvate. Pathway analysis revealed that these metabolites were mainly involved in tryptophan metabolism, purine metabolism, nicotinate and nicotinamide metabolism, phenylalanine metabolism, histidine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, tyrosine metabolism, arginine and proline metabolism, arachidonic acid metabolism, and caffeine metabolism.
conclusionsThese findings suggest that C. perfringens type A infection causes a duck spleen inflammatory response and immune response in infected ducks through indolin-2-one, 3-methylindole, 4-hydroxy-2-quinolinecarboxylic acid and tryptophan metabolism, purine metabolism, nicotinic acid and nicotinamide metabolism, which provides a basis for understanding the pathogenesis of C. perfringens type A in ducks.
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