Observational studyBMC oral health2025
Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?
Observational study in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06627972 (IS THERE A RELATIONSHIP BETWEEN PERIODONTAL CONDITION AND ASPROSIN LEVEL IN GINGIVAL CREVICULAR FLUID?), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is there a relationship between periodontal condition and asprosin level in gingival crevicular fluid?
Who cites it
4 citing papers in PubMed.
- Salivary asprosin, IL-39, IL-40, and IL-1β levels in diabetic patients with periodontitis: A cross-sectional analysis.Clinical oral investigations · 2026Trial
- Serum and gingival crevicular fluid asprosin levels in obese and normal-weight individuals with and without periodontitis: a cross-sectional study.BMC oral health · 2026Article
- Salivary Apelin and Asprosin Levels in Periodontitis and Diabetes Mellitus and Their Relationship with Clinical Periodontal Parameters.Diagnostics (Basel, Switzerland) · 2026Article
- Serum asprosin levels as a potential prognostic biomarker in COVID-19: insights for future respiratory viral pandemics.BMC infectious diseases · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesThis study aimed to investigate the presence of asprosin hormone in the biological fluids of patients with periodontal inflammation and compare it to those with periodontal healthy. MATERIALS AND
methodsSeventy-five individuals between the ages of 18 to 45, 25 periodontal healthy, 25 with gingivitis, and 25 with periodontitis, were included in the study. Gingival crevicular fluid (GCF), blood serum and saliva were obtained from individuals in each group. Tumour necrosis factor-alpha (TNF-α) and asprosin levels in these fluids were determined using the ELISA. Clinical periodontal measurements were recorded and body mass index was calculated. One-way ANOVA and Bonferroni tests were performed for statistical analysis. Spearman test was used to evaluate correlations. The significance level was determined as p < 0.05.
resultsBody mass index values were not different between the groups (p = 0.446). Clinical periodontal measurements were significantly higher in the periodontitis group. Concentrations of TNF-α in GCF, serum and saliva increased significantly in patients with gingivitis and periodontitis (p < 0.001). The higher TNF-α levels were obtained in patients with periodontitis than in individuals with gingivitis (p = 0.001). While asprosin levels were found to be significantly higher in patients with gingivitis and periodontitis (p < 0.001), no significant difference was observed between both groups (p > 0.05). GCF-asprosin levels were positively correlated with the concentrations in serum and saliva in all individuals included in the study (p < 0.05).
conclusionThe periodontal inflammation caused an increase in asprosin hormone in gingival crevicular fluid independently of the type of periodontal disease.
trial registrationThis study is registered with number of "NCT06627972" in ClinicalTrials.gov website from the date of October 3, 2024.
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