ArticleBMC oral health2025
Evaluation of trabecular bone microstructure and cortical morphology using cone-beam and micro-CT images: impact of tube voltage setting.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Dimensional Accuracy and Clinical Fitness of Customized 3D-Printed Hydroxyapatite Bone Block Grafts in Alveolar Ridge Augmentation.European journal of dentistry · 2026Article
- Adjacent Maxillary Bone Microarchitecture in Patients with Asymmetric Bilateral Lund-Mackay Scores: A Pilot Retrospective Within-Subject Analysis Using CBCT.Diagnostics (Basel, Switzerland) · 2026Article
- Defined Microbiota Modulates Host Metabolome and Skeletal Adaptation to Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles combined with injectable hydrogels in bone defect repair: a systematic review and meta-analysis of preclinical studies.Journal of biological engineering · 2026Review
- Photon-counting detector CT virtual monoenergetic imaging for bone mineral density quantification: Validation with Micro-CT.iScience · 2026Article
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Authors and funding
4 authors.
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Abstract
objectiveTo evaluate the effect of various tube voltage (kV) settings on the accuracy of cone-beam computed tomography (CBCT) images in measuring trabecular microstructure and cortical morphology, using micro-CT (μCT) as the reference.
methodsTen bone samples of sheep mandibles were scanned using both μCT and CBCT at three different tube voltage settings (80, 85, and 90 kV). Identical regions of interest (ROIs) on trabecular and cortical bones were analyzed in all images. Measurements of trabecular microstructure included bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and space (Tb.Sp), while thickness (Ct.Th) and area (Ct.Ar) of cortical bone were measured to determine cortical morphology. Measurements were compared using paired t-test, while agreement between measurements of two modalities was assessed using Bland-Altman analysis. One-way ANOVA was used to determine differences in measurements of CBCT images at different kVs (p < 0.01).
resultsCompared to μCT, CBCT overestimated trabecular parameters and Ct.Th but underestimated Ct.Ar, with high agreement observed between the methods. Significant differences were found for all measurements except BV/TV and Ct.Ar at all kVs. No differences were observed between CBCT measurements at different tube potentials.
conclusionThe tube voltage of CBCT has minimal impact on the measurement accuracy of most microstructural parameters. BV/TV and Ct.Ar measurements may be particularly preferred for bone evaluations using CBCT images.
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