SynthesisBMC pediatrics2025
The value of intestinal fatty acid binding protein as a biomarker for the diagnosis of necrotizing enterocolitis in preterm infants: a meta-analysis.
Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- LncRNAs as Emerging Diagnostic Biomarkers for Cardiovascular Diseases: Evidence Synthesis Through Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Intestinal Biomarkers in Preterm Infants: Influence of Mother's Own Milk on Fecal Calprotectin and of Gestational Age on IFABP Concentrations.Nutrients · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundNecrotizing enterocolitis (NEC) is a serious condition mainly affecting newborns, especially preterm or low birth weight ones, with a poor prognosis. The present study aimed to comprehensively evaluate the diagnostic value of intestinal-type fatty acid-binding protein (I-FABP) in NEC through meta-analysis.
methodsRelevant documents on the diagnosis of I-FABP in neonatal NEC were retrieved from PubMed, ScienceDirect, Embase, Cochrane, Wanfang, and CNKI databases. Summary receiver operating characteristic curve (SROC), sensitivity, specificity, and likelihood ratio (LR) were constructed to evaluate the pooled diagnostic value. Meta-regression analysis was conducted to explore the sources of heterogeneity. Sensitivity analysis was performed to detect the robustness of current results.
resultsThe present study encompassed 15 studies. I-FABP had a high diagnostic value for NEC, with a sensitivity at 0.78 (0.70-0.85), a specificity of 0.85 (0.78-0.90), and the area under the curve (AUC) value was 0.89 (0.86-0.91). The combined diagnostic odds ratio (DOR) was 20.33 (10.90-37.90) indicating a high diagnostic potential with strong discriminatory power. Sample source, detection method, and critical value might be the source of heterogeneity. There was no significant publication bias.
conclusionI-FABP played a crucial role in diagnosing NEC in premature infants.
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