ArticleBMC cancer2025
Nasopharyngeal necrosis following intensity-modulated radiation therapy of primary nasopharyngeal carcinoma-incidence rate and predictors of risk.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Complementary roles of GPU-accelerated Monte Carlo and ArcCHECK in TomoTherapy quality assurance.Physical and engineering sciences in medicine · 2026Article
- Prognostic indicators and microbial landscape of post-radiation nasopharyngeal necrosis in nasopharyngeal carcinoma patients.Journal of the Chinese Medical Association : JCMA · 2026Article
- Dose-guided individualized planning target volume margin optimization in nasopharyngeal carcinoma: a retrospective megavoltage computed tomography-based cumulative analysis.Frontiers in oncology · 2025Article
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Abstract
objectivesThis study aimed to investigate the incidence of post radiation nasopharyngeal necrosis (PRNN) in primary NPC after intensity modulated radiation therapy (IMRT) and identify the predictors of risk.
methodsData of 5798 NPC patients who received IMRT-based treatment between April 2009 and December 2015 were retrospectively reviewed. PRNN was diagnosed by MRI or nasopharyngoscopy. Dosimetric factors were selected by the least absolute shrinkage and selection operator logistic regression and applied to Cox proportional hazards modeling with clinical predictors.
resultsAmong the 5798 patients, 53 developed PRNN-an incidence rate of 0.89%. Age > 55 years, diabetes, LDH > 170 U/L, and tumor volume of nasopharynx > 60.5 cm
conclusionNasopharyngeal necrosis is rare after primary IMRT. The independent risk factors for this rare complication include age > 55 years, diabetes mellitus, LDH > 170 U/L, tumor volume of nasopharynx > 60.5 cm KEYPOINTS: High radiation dose may lead to devastating nasopharyngeal necrosis after primary IMRT. Real world analysis will provide valuable information for prevention.
findingsThe aged, diabetes mellitus, large tumor volume, D CLINICAL RELEVANCE: This real-world study provided valuable information for prevention of PRNN. Compared with RTOG protocol, D
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