SynthesisBMC infectious diseases2025
Differences in chest imaging between Omicron and non-Omicron coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association Between ADA (Age-D-dimer-Albumin) Score and Chest CT Severity Score in COVID-19 Pneumonia.Journal of personalized medicine · 2026Article
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4 authors.
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Abstract
backgroundCoronavirus disease 2019 (COVID-19) have posed a great threat to human health. We carried out this systematic review and meta-analysis for two objectives. First, to evaluate the differences in lung infection between the Omicron variants and the non-Omicron strains by chest computed tomography (CT); second, to evaluate the differences in chest CT features between COVID-19 patients with the Omicron variants and those with non-Omicron strains in CT-positive cases.
methodsWe searched PubMed, Embase, Web of Science and China National Knowledge Infrastructure for articles and performed a meta-analysis using Stata 14.0 with a random effects model.
resultsOur study included a total of 8126 patients with COVID-19, 4113 with the Omicron variants, and 4013 with non-Omicron strains. Patients with the Omicron variants were less likely to be CT-positive (OR = 0.14, 95% CI: 0.08-0.25), and further analysis among CT-positive patients was performed. Compared with the CT images of patients with non-Omicron strains, those of patients with the Omicron variants showed atypical pulmonary features (OR = 4.02, 95% CI: 2.31-6.98). Moreover, patients with the Omicron variants typically had lesions that were mainly located in the center of the lung (OR = 4.51, 95% CI: 1.38-14.76) and in a single lobe (OR = 1.72, 95% CI: 1.10-2.70). The patients with the Omicron variants were less likely to have lesions in both lungs (OR = 0.33, 95% CI: 0.15-0.69), more likely to have bronchial wall thickening (OR = 1.99, 95% CI: 1.05-3.77) and less likely to have the crazy-paving pattern (OR = 0.51, 95% CI: 0.33-0.81), linear opacity (OR = 0.26, 95% CI: 0.12-0.60), and vascular enlargement (OR = 0.54, 95% CI: 0.35-0.84).
conclusionsThrough meta-analysis, which yields the highest level of evidence for evidence-based medicine, we further confirmed that there were significant differences in the distribution and manifestations of lesions between patients with non-Omicron strains and those with the Omicron variants on chest CT. The variation in SARS-CoV-2 has never stopped. Our findings are useful for the diagnosis and treatment of new SARS-CoV-2 variants that may appear in the future and provide a basis for public health decision-making. PROSPERO REGISTRATION NUMBER: CRD42024581869.
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