ArticleBMC psychiatry2025
Differences in cognitive deficits and brain functional impairments between patients with first-episode and recurrent depression.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- No Cognitive Scarring Over 20 Years in Recurrent Depression: Bidirectionality of Cognitive Functioning and Depression.Clinical psychology in Europe · 2026Article
- Bilateral repetitive transcranial magnetic stimulation modulates the hemispheric imbalance in major depressive disorder.General psychiatry · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAccumulating evidence shows that cognitive deficits are common in patients with major depressive disorder (MDD). However, the specific differences in cognitive impairment and brain functional alterations between first-episode depression (FED) and recurrent major depression (RMD) remain unclear, as do the relationships among these factors.
methodsA total of 43 RMD and 41 FED patients were included in this study. All the patients underwent examinations of resting-state functional magnetic resonance imaging (fMRI), event-related potential (ERP) measurements, and a series of standardised neuropsychological tests, including event-based (EBPM) and time-based (TBPM) prospective memory tasks, the Semantic Fluency Test (SFT), and the Continuous Performance Task-Identical Pairs (CPT-IP). Two-sample t-tests were used to compare cognitive functioning, ERP parameters, and brain functional indices between FED and RMD groups. Correlation analyses were performed to explore the associations between these variables.
resultsCompared with FED patients, those with RMD displayed poorer CPT-IP performance, lower prospective memory (EBPM) scores, lower SFT performance, and prolonged P300 latency (all P < 0.05). Moreover, neuroimaging data analysis revealed increased regional neural activity in the right inferior temporal gyrus (ITG), alongside decreased interhemispheric functional connectivity in the bilateral ITG in RMD relative to FED. Correlation analyses indicated that these functional changes were significantly associated with the observed cognitive deficits.
conclusionOur data demonstrated more pronounced cognitive deficits and brain functional impairments in RMD relative to FED as well as their potential links. These findings not only elucidate the neural mechanisms underlying cognitive deficits in MDD, but also inform future treatment and prevention of cognitive dysfunction in patients suffering from MDD. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.