ArticleBMC microbiology2025
Cold atmospheric plasma and skin wound healing: influence on microbial diversity and composition.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Three novel bacterial species isolated from plasma-treated soil: Hymenobacter plasmatis sp. nov., Flavitalea plasmicola sp. nov. and Mucilaginibacter tolerans sp. nov.Antonie van Leeuwenhoek · 2026Article
- Review
- Controlled release of berberine modulates the wound microbiome to accelerate wound healing.Asian journal of pharmaceutical sciences · 2026Article
- Cold Plasma as a Revolutionary Antimicrobial Modality: A Multifaceted Weapon Against Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- Bedside inoculation accelerates detection and improves microbiological diagnosis efficiency compared to delayed inoculation.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSkin wound healing presents a complex challenge, often compounded by the risk of infection. Cold atmospheric plasma (CAP) emerged as a novel therapeutic for reducing bacterial load and expediting wound healing. However, its effect on the wound microbiome remained unclear. This study aimed to characterize the microbiome of different types of wounds and determine whether CAP influenced microbial diversity.
methodsTwenty-five patients (ten with acute, fifteen with chronic skin wounds) and ten healthy controls were enrolled. CAP was tailored to individual clinical conditions. Skin samples were collected before and after CAP, and microbiota composition was determined by 16 S ribosomal RNA sequencing.
resultsMicrobial communities differed between acute and chronic groups. CAP could accelerate wound healing. However, it did not change microbial α and β-diversity in acute wounds. In chronic wounds, α-diversity indices, including the chao and ACE, were significantly increased, and a significant clustering was observed in post-CAP group. In addition, CAP led to higher abundance of Staphylococcus, lower levels of Proteobacteria and Pseudomonas in chronic wounds.
conclusionsThis study provided novel insights into the impact of CAP on skin wound microbiota. Further research was required to ascertain causality between microbiota and CAP and to develop personalized CAP treatment strategies.
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Registered trials
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