SynthesisBMC infectious diseases2025
Epidemiology of clinical antimicrobial-resistant Enterobacterales in Togo over three decades: a systematic review and meta-analysis, with recommendations and alternative solutions.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Epidemiological trends in antibiotic resistant Klebsiella pneumoniae in healthcare settings in Burkina Faso: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to the World Health Organization (WHO), surveillance programs have become essential at national, regional, and global levels to adjust empirical treatments and target interventions to prevent and control the emergence of antimicrobial resistance (AMR). Therefore, this study aimed to conduct the first systematic review and meta-analysis of clinical Enterobacterales resistance to 11 representative antimicrobials from the WHO AWaRe (Access, Watch, Reserve) list, and to provide recommendations to tackle AMR more efficiently in Togo.
methodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (The PRISMA 2020) were used to conduct this study and the protocol was registered with PROSPERO (CRD42024606897). Keywords were used to conduct a systematic literature review of electronic databases. Data analysis was conducted using Stata software version 17.0.
resultsTwenty research articles reporting 9,327 clinical Enterobacterales isolates obtained from 1991 to 2020 were included in this review and were mainly Escherichia coli (6,639; 71.2%), and Klebsiella spp. (2,542; 27.3%), mainly isolated from urine (14 studies; 70%), and pus/wounds (12; 60%). The pooled Enterobacterales resistance rates ranged from 1% (95% CI: 0, 2) imipenem, 3% (95% CI: 1, 5) amikacin, 4% (95% CI: 2, 7) fosfomycin, 50% (95% CI: 40, 60) chloramphenicol, 55% (95% CI: 45, 64) gentamicin, 68% (95% CI: 59, 76) ciprofloxacin, 73% (95% CI: 66, 80) amoxicillin/clavulanic acid (AMC), 79% (95% CI: 71, 86) third-generation cephalosporins (3GC), to 90% (95% CI: 86, 93) sulfamethoxazole/trimethoprim (SXT). The most significant upward trend over 30 years was reported for SXT (R
conclusionThis study revealed high first-line AMR rates with drastic upward trends in clinical Enterobacterales isolated in Togo over the past 30 years. Thus, the adjustment of empirical antimicrobial treatments in Togo becomes crucial. Moreover, the implementation of prevention policies, whole-genome sequencing approaches, and the promotion of antibiotic stewardship must be enhanced. Finally, alternative therapeutic approaches, such as phytotherapy and phage therapy, were discussed. CLINICAL TRIAL: Not applicable.
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