Evidence map›Paper›PMID 40301731›Full record

SynthesisBMC cardiovascular disorders2025

Drug-coated balloons versus drug-eluting stents in patients with small coronary artery disease: an updated meta-analysis.

Ahmed Abdelaziz, Hanaa Elsayed, Karim Atta, Muhammad Desouky, Mahmoud Gomaa, Hallas Kadhim, Ahmed Mechi, Mohamed Abdelaziz, Mahmoud Ezzat, Manar Alaa Mabrouk and 7 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ahmed AbdelazizFaculty of Medicine, Al-Azhar University, Cairo, Egypt. ahmedmhmd0144@gmail.com.ORCID 0000-0002-1257-3450
Hanaa ElsayedMedical Research Group of Egypt (MRGE), Cairo, Egypt.
Karim AttaMedical Research Group of Egypt (MRGE), Cairo, Egypt.
Muhammad DesoukyThe Brooklyn Hospital Center, Brooklyn, NY, USA.
Mahmoud GomaaFaculty of Medicine Kafrelsheikh University, Kafrelsheikh, Egypt.
Hallas KadhimAl Muthanna University College of Medicine, Samawah, Iraq.
Ahmed MechiInternal Medicine Department, Medicine College, University of Kufa, Najaf, Iraq.
Mohamed AbdelazizFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mahmoud EzzatMedical Research Group of Egypt (MRGE), Cairo, Egypt.
Manar Alaa MabroukMedical Research Group of Egypt (MRGE), Cairo, Egypt.
Mohamed Hatem EllabbanFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Emad Addin ZawanehMedical Research Group of Egypt (MRGE), Cairo, Egypt.
Abdelrahman HafezFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed Yasser ElnaggarFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed O SenaDepartment of Cardiovascular Medicine, Cairo University Hospitals, Cairo, Egypt.
Ahmed BahnasyHematology and Oncology Department, Mayo Clinic, Scottsdale, AZ, USA.
Emad SingerUniversity of Texas MD Anderson, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug-coated balloons (DCB) have promising results in the management of large coronary artery lesions (CAD), still their role in treating small CAD is not well established. We aimed to provide a comprehensive appraisal of the efficacy and safety of DCBs in patients with small CAD.

methodsWe searched PubMed, Scopus, web of science, Ovid, and Cochrane Central from inception until 30 March, 2023. We included all relevant studies that compared DCB versus drug-eluting stents (DES) in small CAD patients undergoing PCI. We reported clinical outcomes as MACE, all-cause death, cardiac death, MI, TLR, TVR, and stent thrombosis, while angiographic outcomes were late lumen loss (LLL), mean lumen diameter (MLD), net luminal gain (NLG), and in-segment binary restenosis.

resultsTwenty studies comprising 18,469 patients were included in this meta-analysis. The incidence rate of MACE was 9.4% in the DCB group compared to 9.9% in the DES group, without a significant difference in the risk of MACE (OR = 0.97, 95% CI: 0.77 to 1.22, p = 0.78). Moreover, DCB significantly decreased MLD and NLG compared to DES, with the following values, respectively (MD= -0.19, 95% CI: -0.32 to -0.06, p < 0.001, and MD -0.21, 95% CI: -0.40 to -0.01, p = 0.04). On the other hand, DCB was associated with higher odds in the risk of in-segment binary restenosis (OR 1.66, 95% CI: 1.03 to 2.68, p = 0.04).

conclusionDCB is an alternative approach to DES in the management of small CAD and should be validated in daily clinical practice. PROSPERO REGISTRATION: CRD42023413068.

Indexed as

Angioplasty, Balloon, CoronaryCardiac CathetersCoated Materials, BiocompatibleCoronary Artery DiseaseDrug-Eluting StentsAgedFemaleHumansMaleMiddle AgedProsthesis DesignRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeCoated Materials, BiocompatibleDrug-coated balloonDrug-eluting stentMeta-analysisSmall coronary artery disease

Identifiers

PMID40301731
PMCPMC12042378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.