ArticleScientific reports2025
Impact of multimorbidity and cognitive impairment on depressive symptoms in community-dwelling older adults and their interaction effects.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Persistent socio-demographic inequalities in depression among older adults in China during and after COVID-19: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Depressive Symptoms Are the Dominant Independent Correlate of Patient-Reported Cognitive Function in Older Women with Locally Advanced Breast Cancer: A Cross-Sectional Geriatric Assessment Study.Journal of clinical medicine · 2026Article
- The impact of tooth loss on the risk of cognitive impairment among community-dwelling older adults: a prospective cohort study.BMC public health · 2026Article
- Association between multimorbidity and childhood socioeconomic status with depressive symptoms among middle-aged and older adults in rural western China.Scientific reports · 2026Article
- Chronic disease multimorbidity and mental health among older adults in China: The moderating roles of family and social support.PloS one · 2026Article
- The relationship between cognitive impairment and quality of life in rural older adults with chronic diseases-parallel mediating effects of depressive symptoms and frailty.BMC geriatrics · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
This study aims to evaluate the independent and interactive effects of multimorbidity and cognitive impairment on depressive symptoms among older adults in China. Employing a cross-sectional design, the study collected data from 10,369 individuals aged 65 and above across 35 communities/villages in China. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), cognitive function was evaluated with the Alzheimer's Disease-8 (AD-8) scale, and chronic disease conditions were recorded. The results indicated that older adults with multimorbidity (OR = 2.481, 95% CI: 2.117, 2.908) and those at high risk of cognitive impairment (OR = 5.469, 95% CI: 4.644, 6.441) exhibited a higher likelihood of experiencing depressive symptoms. Further interaction analysis revealed that, after controlling for confounding factors, no significant multiplicative interaction was found between multimorbidity and cognitive impairment (P = 0.581); however, a significant additive interaction effect was observed (OR = 13.809, 95% CI: 11.063, 17.237). These findings suggest that multimorbidity and cognitive impairment are important factors associated with depressive symptoms in older adults, and their combined presence is linked to a substantially increased likelihood of experiencing depressive symptoms compared to either condition alone.
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