Evidence map›Paper›PMID 40301587›Full record

ArticleScientific reports2025

Prostate microcalcification crystallography as a marker of pathology.

Sarah B Gosling, Emily L Arnold, Lois Adams, Paul Cool, Kalotina Geraki, Mark O Kitchen, Iain D Lyburn, Keith D Rogers, Tim Snow, Nick Stone and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah B GoslingSchool of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK. s.b.gosling@keele.ac.uk.ORCID http://orcid.org/0000-0002-7034-6547
Emily L ArnoldDiamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
Lois AdamsSchool of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK.
Paul CoolRobert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, SY10 7AG, UK.
Kalotina GerakiDiamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
Mark O KitchenSchool of Medicine, Keele University, Keele, Staffordshire, ST5 5BG, UK.
Iain D LyburnCranfield Forensic Institute, Cranfield University, Shrivenham, SN6 8LA, UK.
Keith D RogersCranfield Forensic Institute, Cranfield University, Shrivenham, SN6 8LA, UK.
Tim SnowDiamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.
Nick StoneDepartment of Physics and Astronomy, University of Exeter, Exeter, EX4 4QL, UK.
Charlene E GreenwoodSchool of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK. c.e.greenwood@keele.ac.uk.ORCID http://orcid.org/0000-0003-1332-3864

Funding

Cancer Research UK EDDPMA-May21\100010
6 · The paper itself

Abstract

Prostate cancer remains the most common male cancer; however, treatment regimens remain unclear in some cases due to a lack of agreement in current testing methods. Therefore, there is an increasing need to identify novel biomarkers to better counsel patients about their treatment options. Microcalcifications offer one such avenue of exploration. Microfocus spectroscopy at the i18 beamline at Diamond Light Source was utilised to measure X-ray diffraction and fluorescence maps of calcifications in 10 µm thick formalin fixed paraffin embedded prostate sections. Calcifications predominantly consisted of hydroxyapatite (HAP) and whitlockite (WH). Kendall's Tau statistics showed weak correlations of 'a' and 'c' lattice parameters in HAP with GG (r

Indexed as

CalcinosisProstateProstatic NeoplasmsBiomarkersBiomarkers, TumorDurapatiteHumansMaleX-Ray DiffractionBiomarkersBiomarkers, TumorDurapatiteBiomarkersCalcificationProstate cancer

Identifiers

PMID40301587
PMCPMC12041448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.