Evidence map›Paper›PMID 40301502›Full record

ArticleScientific reports2025

Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions.

Huseyin Kilili, Benjamin Padilla-Morales, Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Karina Díaz-Barba, Paola Cornejo-Paramo, Orsolya Vincze, Mathieu Giraudeau, Stephen J Bush, Zhidan Li and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Huseyin Kilili *Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
Benjamin Padilla-Morales *Milner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK. bpm29@bath.ac.uk.
Atahualpa Castillo-MoralesUK Dementia Research Institute, Cardiff University, CF24 4HQ, Cardiff, UK.
Jimena Monzón-SandovalUK Dementia Research Institute, Cardiff University, CF24 4HQ, Cardiff, UK.
Karina Díaz-BarbaMilner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
Paola Cornejo-ParamoMilner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
Orsolya VinczeLittoral, Environnement et Sociétés (LIENSs), UMR 7266 CNRS-La Rochelle Université, 2 Rue Olympe de Gouges, FR-17000, La Rochelle, France.
Mathieu GiraudeauLittoral, Environnement et Sociétés (LIENSs), UMR 7266 CNRS-La Rochelle Université, 2 Rue Olympe de Gouges, FR-17000, La Rochelle, France.
Stephen J BushSchool of Automation Science and Engineering, Xi'an Jiaotong University, Xi'an, China.
Zhidan LiKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, 610041, Chengdu, China.
Lu ChenKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, 610041, Chengdu, China.
Evangelos MourkasZoonosis Science Centre, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Sergio AnconaInstituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Alejandro Gonzalez-VoyerInstituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Diego CortezCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, CP62210, Cuernavaca, México.
Humberto GutierrezInstituto Nacional de Medicina Genomica, 14610, Ciudad de Mexico, Mexico.
Tamás SzékelyMilner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
Alín P Acuña-AlonzoInstituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico. accuna@iecologia.unam.mx.
Araxi O UrrutiaMilner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK. a.urrutia@iecologia.unam.mx.

Funding

Frontiers in Science CONACyT FC-2020 / 682142Frontiers in Science CONACyT grant FC-2016 /1682János Bolyai Research Scholarship of the Hungarian Academy of Sciences (HAS) and by the grant of the Ministry of Research, Innovation and Digitization, CNCS - UEFISCDI, project number PN-III-P1-1.1-TE-2021-0502 PNCDI IIINERC grant NE/P004121/1PAPPIT-DGAPA-UNAM grant IA204020Royal Society Newton Advanced Fellowship NA160564
6 · The paper itself

Abstract

Mammals exhibit an unusual variation in their maximum lifespan potential, measured as the longest recorded longevity of any individual in a species. Evidence suggests that lifespan increases follow expansion in brain size relative to body mass. Here, we found significant gene family size expansions associated with maximum lifespan potential and relative brain size but not in gestation time, age of sexual maturity, and body mass in 46 mammalian species. Extended lifespan is associated with expanding gene families enriched in immune system functions. Our results suggest an association between gene duplication in immune-related gene families and the evolution of longer lifespans in mammals. These findings explore the genomic features linked with the evolution of lifespan in mammals and its association with life story and morphological traits.

Indexed as

BrainImmune SystemLongevityMammalsMultigene FamilyAnimalsHumansOrgan SizeAgeingGene duplicationGene expressionGene family sizeImmunityLongevity

Identifiers

PMID40301502
PMCPMC12041557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.