Evidence map›Paper›PMID 40301499›Full record

ArticleScientific reports2025

DNA methylome biomarkers of rheumatoid arthritis-associated interstitial lung disease reflecting lung fibrosis pathways, an exploratory case-control study.

Bartosz Kaczmarczyk, Carlos de la Calle-Fabregat, Adrian Conde, Ana Catarina Duarte, Natalia Mena-Vazquez, Antonio Fernandez-Nebro, Ana Triguero-Martinez, Santos Castañeda, Raquel Dos-Santos Sobrin, Antonio Mera-Varela and 25 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Bartosz Kaczmarczyk *Experimental and Observational Rheumatology and Rheumatology Unit, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Carlos de la Calle-Fabregat *Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain.
Adrian CondeExperimental and Observational Rheumatology and Rheumatology Unit, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Ana Catarina DuarteRheumatology Department, Unidade Local de Saúde de Almada-Seixal - Hospital Garcia de Orta, Almada, Portugal.
Natalia Mena-VazquezDepartment of Rheumatology, University Regional Hospital of Malaga (HRUM). Institute for Biomedical Research in Malaga (IBIMA), Malaga University, Málaga, Spain.
Antonio Fernandez-NebroDepartment of Rheumatology, University Regional Hospital of Malaga (HRUM). Institute for Biomedical Research in Malaga (IBIMA), Malaga University, Málaga, Spain.
Ana Triguero-MartinezRheumatology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria la Princesa (IIS-Princesa), Madrid, Spain.
Santos CastañedaRheumatology Department, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria la Princesa (IIS-Princesa), Madrid, Spain.
Raquel Dos-Santos SobrinExperimental and Observational Rheumatology and Rheumatology Unit, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Antonio Mera-VarelaExperimental and Observational Rheumatology and Rheumatology Unit, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Chary Lopez-PedreraRheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
Alejandro Escudero-ContrerasRheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
Paloma Vela-CasasempereRheumatology Department, Hospital General Universitario Dr Balmis, ISABIAL, Alicante, Spain.
Maria MolinaPneumology Department, Hospital Universitario Belvitge, Barcelona, Spain.
Javier NarvaezRheumatology Department, Hospital Universitario Belvitge, Barcelona, Spain.
Miriam Retuerto-GuerreroRheumatology Department, Hospital 12 de Octubre and Universidad Complutense de Madrid, Madrid, Spain.
Jose L PablosRheumatology Department, Hospital 12 de Octubre and Universidad Complutense de Madrid, Madrid, Spain.
Juan C Sarmiento-MonroyRheumatology Department, Hospital Clinic and IDIBAPS, Barcelona, Spain.
Raimon SanmartiRheumatology Department, Hospital Clinic and IDIBAPS, Barcelona, Spain.
Luis Gomez-CarreraPneumology Department, Instituto de Investigación Hospital Universitario La Paz (IDIPAZ), Madrid, Spain.
Gema BonillaRheumatology Department, Instituto de Investigación Hospital Universitario La Paz (IDIPAZ), Madrid, Spain.
Sara Remuzgo-MartinezRheumatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain.
Miguel Angel Gonzalez-GayDepartment of Medicine and Psychiatry, University of Cantabria, Santander, Spain.
Virginia Leiro-FernandezPneumology Department, NeumoVigo I+i Research Group, Complejo Hospitalario Universitario de Vigo, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO. CIBERES. ISCIII, Vigo, Spain.
Nair Perez-GomezRheumatology Unit, Hospital Alvaro Cunqueiro, Vigo, Spain.
Cristina Vadillo-FontRheumatology Department, Hospital Clínico San Carlos - Instituto Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
Lydia AbasoloRheumatology Department, Hospital Clínico San Carlos - Instituto Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
Ivette Casafont-SoleRheumatology Department, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
Lourdes Mateo-SoriaRheumatology Department, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
Ana Cristina Castillo-GonzalezRheumatology Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Carlos MarrasRheumatology Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Eva Perez-PampinExperimental and Observational Rheumatology and Rheumatology Unit, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Esteban Ballestar *Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain.
Antonio Gonzalez *Experimental and Observational Rheumatology and Rheumatology Unit, Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. agmartinezp@ser.es.
MARILD network

Funding

Instituto de Salud Carlos III PI20/01268Instituto de Salud Carlos III PI23/00841Instituto de Salud Carlos III RD21/0002/0003
6 · The paper itself

Abstract

Rheumatoid Arthritis-associated Interstitial Lung Disease (RA-ILD) significantly reduces life quality and survival, necessitating improvements in its understanding and clinical management. We addressed these goals using DNA methylation analysis, which has not been done in RA-ILD samples, by comparing 32 RA patients with ILD diagnosed less than one year before (cases) and 32 matched RA patients without ILD (controls). This analysis identified 6679 differentially methylated positions (DMPs) with Δβ ≥ 2% and FDR < 0.05, and 576 differentially methylated regions in RA-ILD. Some DMPs were near mucin, collagen, and telomere maintenance genes. Also, the most notably enriched gene set (up to p

Indexed as

Arthritis, RheumatoidDNA MethylationEpigenomeLung Diseases, InterstitialPulmonary FibrosisAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedBiomarkersBiomarkersDNA methylationEpigeneticsInterstitial lung diseaseLung fibrosisRheumatoid arthritis

Identifiers

PMID40301499
PMCPMC12041357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.