Evidence map›Paper›PMID 40301467›Full record

ArticleScientific reports2025

Development of an artificial intelligence powered software for automated analysis of skeletal muscle ultrasonography.

Zoe Calulo Rivera, Felipe González-Seguel, Arimitsu Horikawa-Strakovsky, Catherine Granger, Aarti Sarwal, Sanjay Dhar, George Ntoumenopoulos, Jin Chen, V K Cody Bumgardner, Selina M Parry and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. Assessing the reliability of interprofessional raters on peripheral muscle ultrasonography in pediatric oncology: A prospective observational study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Observational
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Zoe Calulo RiveraDepartment of Physiotherapy, School of Health Sciences, The University of Melbourne, Melbourne, Australia.
Felipe González-SeguelCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Arimitsu Horikawa-StrakovskyCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Catherine GrangerDepartment of Physiotherapy, School of Health Sciences, The University of Melbourne, Melbourne, Australia.
Aarti SarwalDepartment of Neurology, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Sanjay DharDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.
George NtoumenopoulosDepartment of Physiotherapy, St. Vincent's Hospital, Sydney, Australia.
Jin ChenDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
V K Cody BumgardnerInstitute for Biomedical Informatics, University of Kentucky, Lexington, KY, USA.
Selina M ParryDepartment of Physiotherapy, School of Health Sciences, The University of Melbourne, Melbourne, Australia.
Kirby P MayerCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA. kpmaye2@uky.edu.
Yuan WenCenter for Muscle Biology, University of Kentucky, Lexington, KY, USA. ywen2@uky.edu.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Muscle and physical function recovery after acute critical illnessR01AR081002 · NIAMS · UNIVERSITY OF KENTUCKY · PI Esther E Dupont-Versteegden · 2023 to 2026
$1.7M
Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical IllnessK23AR079583 · NIAMS · UNIVERSITY OF KENTUCKY · PI Kirby P Mayer · 2022 to 2026
$744k
Contribution of ribosome specialization to the pathophysiology of muscular dystrophyR00AR081367 · NIAMS · UNIVERSITY OF KENTUCKY · PI YUAN WEN · 2024 to 2026
$719k
AIMS - Artificial intelligence in Medicine Alliance of the University of Kentucky and by the NIH National Center for Advancing Translational Sciences UL1TR001998National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institute of Health K23-AR079583National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institute of Health R00-AR081367NIAMS NIH HHS K23 AR079583NIAMS NIH HHS R00 AR081367NIAMS NIH HHS R01 AR081002NIMHD NIH HHS L32 MD017732
6 · The paper itself

Abstract

Muscle ultrasound has high utility in clinical practice and research; however, the main challenges are the training and time required for manual analysis to achieve objective quantification of muscle size and quality. We aimed to develop and validate a software tool powered by artificial intelligence (AI) by measuring its consistency and comparability of expert manual analysis quantifying lower limb muscle ultrasound images. Quadriceps complex (QC) and tibialis anterior (TA) muscle images of healthy, intensive care unit, and/or lung cancer participants were captured with portable devices. Manual analyses of muscle size and quality were performed by experienced physiotherapists taking approximately 24 h to analyze all 180 images, while automated analyses were performed using a custom-built deep-learning model (MyoVision-US), taking 247 s (saving time = 99.8%). Consistency between the manual and automated analyses was good to excellent for all QC (ICC = 0.85-0.99) and TA (ICC = 0.93-0.99) measurements, even for critically ill (ICC = 0.91-0.98) and lung cancer (ICC = 0.85-0.99) images. The comparability of MyoVision-US was moderate to strong for QC (adj. R

Indexed as

Artificial IntelligenceImage Processing, Computer-AssistedMuscle, SkeletalSoftwareAdultAgedDeep LearningFemaleHumansLung NeoplasmsMaleMiddle AgedQuadriceps MuscleUltrasonographyArtificial intelligenceAutomation softwareMedical image analysisSkeletal muscleUltrasound

Identifiers

PMID40301467
PMCPMC12041593

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.