Evidence map›Paper›PMID 40301414›Full record

ArticleScientific reports2025

Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI: an exploratory study.

Max Gebest, Christel Weiß, Chang-Gyu Cho, Lucrezia Hausner, Lutz Frölich, Alex Förster, Nandhini Santhanam, Johann Fontana, Christoph Groden, Holger Wenz and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Max GebestDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.ORCID http://orcid.org/0009-0009-6244-6925
Christel WeißDepartment of Medical Statistics, Biomathematics and Information Processing, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Chang-Gyu ChoDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Lucrezia HausnerCentral Institute of Mental Health (ZI/CIMH), J5, 68159, Mannheim, Germany.
Lutz FrölichCentral Institute of Mental Health (ZI/CIMH), J5, 68159, Mannheim, Germany.
Alex FörsterDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Nandhini SanthanamDepartment of Biomedical Informatics at the Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Johann FontanaDepartment of Anesthesiology and Intensive Care Medicine, BG Trauma Center Tuebingen, 72076, Tuebingen, Germany.
Christoph GrodenDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Holger Wenz *Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Máté E Maros *Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. maros@uni-heidelberg.de.ORCID http://orcid.org/0000-0002-1589-8699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Automated tools have been proposed to quantify brain volume for suspected dementia diagnoses. However, their robustness in longitudinal, real-life cohorts remains unexplored. This exploratory study examined if expert visual assessment (EVA) of atrophy progression is reflected by automated volumetric analyses (AVA) on sequential MR-imaging. We analyzed a random subset of 20 patients with two consecutive 3D T1-weighted examinations (median follow-up 4.0 years, LQ-UQ: 2.1-5.2, range: 0.2-10). Thirteen (65%) with cognitive decline, the remaining with other neuropsychiatric diseases. EVA was performed by two blinded neuroradiologists using a 3 or 5-point Likert scale for atrophy progression (scores

Indexed as

BrainDementiaMagnetic Resonance ImagingAgedAged, 80 and overAtrophyCognitive DysfunctionDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedOrgan SizeAutomated brain volumetryDementiaMorphometryVisual assessment

Identifiers

PMID40301414
PMCPMC12041260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.