Evidence map›Paper›PMID 40301405›Full record

ArticleScientific reports2025

Design, synthesis and biological evaluation of novel kojic acid triazole hybrids as tyrosinase inhibitors and antibrowning agents.

Dan Liu, Junyuan Tang, Sheng Tao, Dahan Wang, Jinbing Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dan LiuDepartment of Food and Chemical Engineering, Shaoyang University, Shao Shui Xi Road, Shaoyang, 422100, China.
Junyuan TangDepartment of Food and Chemical Engineering, Shaoyang University, Shao Shui Xi Road, Shaoyang, 422100, China.
Sheng TaoDepartment of Food and Chemical Engineering, Shaoyang University, Shao Shui Xi Road, Shaoyang, 422100, China.
Dahan WangDepartment of Food and Chemical Engineering, Shaoyang University, Shao Shui Xi Road, Shaoyang, 422100, China.
Jinbing LiuDepartment of Food and Chemical Engineering, Shaoyang University, Shao Shui Xi Road, Shaoyang, 422100, China. syuliujb@163.com.

Funding

Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province Xiangjiaotong[2023] NO. 233Hunan Provincial Natural Science Foundation of China 2025JJ70200Scientific Research Project of Hunan Education Department 22A0536
6 · The paper itself

Abstract

In this study, two series of kojic acid triazole hybrids, namely 6a-6p and 13a-13t, were designed and synthesized. Subsequently, their biological activities including anti-tyrosinase, antioxidant, and as anti-browning effects were investigated. The results showed that most of compounds demonstrated excellent inhibitory effect against mushroom tyrosinase compared with standard reference drug (kojic acid, IC

Indexed as

Enzyme InhibitorsMonophenol MonooxygenasePyronesTriazolesAgaricalesAntioxidantsDrug DesignHumansMolecular Docking SimulationStructure-Activity RelationshipAntioxidantsEnzyme Inhibitorskojic acidMonophenol MonooxygenasePyronesTriazolesAnti-browning effectAntioxidant activityInhibition mechanismKojic acid-triazole hybridsTyrosinase inhibitory activity

Identifiers

PMID40301405
PMCPMC12041489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.