ArticleScientific reports2025
Selective apoptosis induction by antimicrobial peptide TP4 in MCF-7 breast cancer cells.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Anticancer effects of alpha-helical peptide epinecidin-1 and its variants in combination with doxorubicin.Medical oncology (Northwood, London, England) · 2026Article
- Bee derived Aspergillus oryzae as a novel reservoir for selective anticancer metabolites with integrated bioprocess optimization and multi cell line evaluation.BMC microbiology · 2026Article
- EGFR-Targeted and MMP-Activated Membranolytic Peptides Kill Cancer Cells Specifically In Vitro and Reduce Tumor Growth In Vivo.Molecular pharmaceutics · 2026Article
- Harnessing Membrane-Active Peptides for Selective Cancer Targeting: Phosphatidylserine Recognition by Tilapia Piscidin 4.JACS Au · 2026Article
- Antimicrobial peptides for anticancer and antiviral therapy: last promising update.Discover oncology · 2025Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs), including Tilapia piscidin 4 (TP4), have emerged as a promising therapeutic approach for treating different types of cancers. These peptides specifically target tumor cells while minimizing harm to normal tissues. This study aims to investigate the cytotoxic effects of TP4 and elucidate its molecular mechanisms of apoptosis in MCF-7 human breast cancer cell line. MCF-7 and MCF-10 cell viability was assessed after treating the cells with various concentrations of TP4 for 24 h using the MTT assay. The MCF-7 cells were allocated into three groups including control cells (Cnt), cells treated with 0.5 IC
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