ArticleNature communications2025
Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- Towards maximizing optical access through Smart Dura.Journal of neural engineering · 2026Article
- Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Carbon based functional materials enable multifunctional flexible strain sensors for wearable and implantable applications.Discover nano · 2026Review
- PEDOT: PSS for Implantable and Wearable Bioelectronics: From Material Engineering and Energy Storage to Clinical Translation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Structurally engineered ultrasoft PEDOT:PSS fiber microelectrodes with enhanced electrochemical performance for neural interfaces.Science advances · 2026Article
- Microfluidic Spinning Boosting Thermoelectric Performance of PEDOT:PSS Nonwoven Fabrics.Nano-micro letters · 2026Article
- Simultaneous In Vivo Electrophysiology, Two-Photon Imaging, and Optogenetics for Probing Neurovascular Coupling.Methods and protocols · 2026Article
- Transparent Transfer-Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Photo-Patternable PEDOT:PSS for High Performance Organic Electrochemical Transistors.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- PEDOT:PSS in peripheral nerve injury repair: electrical stimulation, neural interfaces, and neural regenerative mechanisms.Materials today. Bio · 2026Review
- Multi-scale imaging and recording of in-vivo neural activity.BMB reports · 2026Review
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- Conducting Polymers for Electrochemical Sensing: From Materials and Metrology to Intelligent and Sustainable Biointerfaces.Sensors (Basel, Switzerland) · 2026Review
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- PEDOT:PSS as a Bio-Solid Electrolyte Interphase for Neural Interfaces: From Molecular Design to Interfacial Intelligence.Polymers · 2025Review
- Single-Step Patterning of Biocompatible Neural Electrodes Using Black-Pt Functionalized Laser-Induced Graphene for in Vivo Electrophysiology.Small methods · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Simultaneous two-photon imaging and electrophysiological recordings offer considerable potential for advancing neurological research and therapies. However, traditional metal-based neural interfaces suffer from photoelectric artifacts, while existing transparent implants rely on opaque interconnect lines to address conductivity limitations. Herein, we developed an optically transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) neural electrode array with transparent electrodes and interconnect lines. Through a formamide, phosphoric acid, and ethylene glycol treatment, the metal-free PEDOT:PSS array achieved an impedance of 45.8 kΩ (at 1 kHz) even with a 20 × 20 µm² size. This advanced performance surpasses previous metal-free transparent neural interfaces and facilitates precise electrophysiological recordings, including extracellular action potentials and low-noise local field potentials. In vivo experiments demonstrated artifact-free two-photon imaging and reliable neural signal acquisition, while biocompatibility tests confirmed negligible cytotoxicity or immune responses. The developed metal-free PEDOT:PSS array provides a robust platform for neural recording and bioimaging, representing an advancement in transparent neural interface technology and integrated optical modalities.
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Registered trials
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