ArticleScientific reports2025
Associations between the risk of LUTS/BPH and the number and class of chronic diseases among middle-aged and elder men.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Lower Urinary Tract Symptoms and Cognitive Impairment Among Participants in the REGARDS Cohort Study.Journal of the American Geriatrics Society · 2026Article
- Nursing strategies for managing urological disorders in aging populations: a comprehensive review.BMC urology · 2026Review
- Incidence and risk factors of LUTS associated with benign prostatic hyperplasia among Chinese men: findings from the CHARLS cohort.Scientific reports · 2026Article
- Airborne chloride exposure and benign prostatic hyperplasia risk.BMC research notes · 2025Article
- Urban-Rural Differences in Self-Reported Physician-Diagnosed BPH and Associated Factors Among Older Men: A Cross-Sectional Analysis of a National Survey.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We explored the associations between the risk of lower urinary tract symptoms suggestive of benign prostatic hyperplasia(LUTS/BPH) and the number and class of chronic diseases via cross-sectional and longitudinal studies.This study included 5197 men aged ≥ 45 years from the China Health and Retirement Longitudinal Study(CHARLS) 2011 with a 7-year follow-up. We multidimensionally investigated the relationships between LUTS/BPH and multimorbidity via latent class analysis, generalized additive analysis and causal mediation analysis. Latent class analysis identified four morbidity classes as follows: minimal or least common diseases (class 1, N = 4160, reference), dominant chronic lung diseases(class 2, N = 152), multiple chronic diseases(class 3, N = 387), and dominant heart diseases or risks(class 4, N = 498). In both the cross-sectional and cohort studies, the risk of LUTS/BPH increased in a dose-dependent manner with the number of chronic diseases. All multivariable-adjusted analyses suggested that three other classes had significantly greater risks of LUTS/BPH than did class 1. In the cross-sectional study, the risk of LUTS/BPH increased by 3.19 times(95%CI: 2.41 to 4.21) in class 3 than in class 1. Causal mediation analyses revealed that depression significantly mediated the association between LUTS/BPH and multimorbidity. Our results suggest that both the number and class of chronic diseases significantly affect the risk of LUTS/BPH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.