Evidence map›Paper›PMID 40301376›Full record

ArticleNature communications2025

Evolutionary history of magnoliid genomes and benzylisoquinoline alkaloid biosynthesis.

Yiheng Hu, Jinpeng Wang, Lumei Liu, Xin Yi, Xin Wang, Jianyu Wang, Ya'nan Hao, Liuyu Qin, Kunpeng Li, Yishan Feng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Genome-Wide Identification and Functional Verification of CoreInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Article
  4. PhytoKeys · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yiheng Hu *State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Jinpeng Wang *State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-2253-7752
Lumei Liu *State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Xin Yi *State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Xin Wang *State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-8441-6836
Jianyu WangState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Ya'nan HaoDepartment of Bioinformatics, School of Life Sciences, North China University of Science and Technology, Tangshan, China.
Liuyu QinState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Kunpeng LiState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Yishan FengDepartment of Bioinformatics, School of Life Sciences, North China University of Science and Technology, Tangshan, China.
Zhongshuai ZhangState Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, China.
Hanying WuKey Laboratory of Systematic and Evolutionary Botany, Institute of Botany, the Chinese Academy of Sciences, Beijing, China.
Yuannian JiaoState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, the Chinese Academy of Sciences, Beijing, China. jiaoyn@ibcas.ac.cn.ORCID http://orcid.org/0000-0002-8987-2782

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32221001
6 · The paper itself

Abstract

Benzylisoquinoline alkaloids (BIAs) are important metabolites synthesized in early-diverging eudicots and magnoliids, yet the genetic basis of BIA biosynthesis in magnoliids remains unclear. Here, we decode the genomes of two magnoliid species, Saruma henryi and Aristolochia manshuriensis, and reconstruct the ancestral magnoliid karyotype and infer the chromosomal rearrangement history following magnoliid diversification. Metabolomic, transcriptomic, and phylogenetic analyses reveal the intermediate chemical components and genetic basis of BIA biosynthesis in A. manshuriensis. Although the core enzymes involved in BIA synthesis appear to be largely conserved between early-diverging eudicots and magnoliids, the biosynthetic pathways in magnoliids seem to exhibit greater flexibility. Significantly, our investigation of the evolutionary history of BIA biosynthetic genes revealed that almost all were duplicated before the emergence of extant angiosperms, with only early-diverging eudicots and magnoliids preferentially retaining these duplicated genes, thereby enabling the biosynthesis of BIAs in these groups.

Indexed as

AlkaloidsBenzylisoquinolinesEvolution, MolecularGenome, PlantMagnoliopsidaBiosynthetic PathwaysPhylogenyAlkaloidsBenzylisoquinolines

Identifiers

PMID40301376
PMCPMC12041406

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.