ReviewAdvances in experimental medicine and biology2025
The Biology and Regulation of Spermatogonial Stem Cells in the Niche.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Spermatogenesis, the process responsible for the daily production of millions of sperm, originates from spermatogonial stem cells (SSCs). Dysregulation of spermatogenesis is a major contributing factor to male infertility. Additionally, cryopreservation of SSCs followed by transplantation is a viable approach to restore spermatogenesis after sterilizing treatments such as chemotherapy and radiotherapy for cancer treatment. Therefore, investigating the biology and regulatory mechanisms involved in maintaining SSCs will provide valuable insights into the etiology of male fertility disorders and inform clinical strategies for fertility preservation and restoration. In this chapter, we will review the origin of SSCs, their biological and functional properties, and the various types of cells that contribute to the SSC niche. Additionally, we will discuss the regulation of SSC self-renewal and differentiation by niche factors, cell-cell and cell-extracellular matrix interactions, intrinsic gene regulation, and emerging intercellular communication mechanisms.
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Registered trials
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