Evidence map›Paper›PMID 40301249›Full record

ReviewDrug delivery and translational research2025

Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases.

Rami Ahmed, Frederic Tewes, Marique Aucamp, Admire Dube

Abstract readReview
In one paragraph

Review in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rami AhmedSchool of Pharmacy, University of the Western Cape, Robert Sobukwe Road, Bellville, 7535, Cape Town, South Africa.
Frederic TewesINSERM U1070, Pôle Biologie-Santé - B36, 1 Rue Georges Bonnet, 51106, 86073, POITIERS Cedex 9, TSA, France.
Marique AucampSchool of Pharmacy, University of the Western Cape, Robert Sobukwe Road, Bellville, 7535, Cape Town, South Africa.
Admire DubeSchool of Pharmacy, University of the Western Cape, Robert Sobukwe Road, Bellville, 7535, Cape Town, South Africa. adube@uwc.ac.za.ORCID 0000-0002-5684-6094

Funding

Nanoparticle-based host-directed therapies for eradication of Mycobacterium tuberculosisR01AI152109 · NIAID · STELLENBOSCH UNIVERSITY · PI DUBE, ADMIRE, REINEKE, JOSHUA JAMES · 2020 to 2024
$1.6M
National Institute of Allergy and Infectious Diseases R01AI152109National Research Foundation of South Africa UID 151628NIAID NIH HHS R01 AI152109
6 · The paper itself

Abstract

Pulmonary infections caused by bacteria, viruses and fungi are a significant global health issue. Inhalation therapies are gaining interest as an effective approach to directly target infected lung sites and nanoparticle-based pulmonary delivery systems are increasingly investigated for this purpose. In this review, we provide an overview of common pulmonary infectious diseases and review recent work on the application of inhalable nanoparticle-based formulations for pulmonary infectious diseases, the formulation strategies, and the current research for delivering inhalable nanomedicines. We also evaluate the current clinical development status, market landscape, and discuss challenges that impede clinical translation and propose solutions to overcome these obstacles, highlighting promising opportunities for future advancements in the field. Despite advancements made and products reaching the market, notable gap persists in translational research, with challenges in achieving the target product profile, availability of appropriate in vivo disease models, scale-up, and market related questions, likely hindering research translation to the clinic.

Indexed as

Lung DiseasesNanomedicineNanoparticlesRespiratory Tract InfectionsAdministration, InhalationAnimalsDrug CompoundingDrug Delivery SystemsHumansTranslational Research, BiomedicalClinical translation of inhaled nanomedicinesInfectious diseases and nanomedicineInhalable nanoparticleNanoparticle pulmonary drug delivery

Identifiers

PMID40301249
PMCPMC12350522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.