ArticleAging clinical and experimental research2025
Temporal association between chronic pain and frailty occurrence, and the modifiable role of a healthy lifestyle in Chinese middle-aged and older population: a community based, prospective cohort study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Single-Cell Transcriptomics of Pyrimidine Salvage in HBV-Related HCC Reveals Prognostic and Immune Infiltration Features.Biomolecules & therapeutics · 2026Article
- Cognitive Impairment and Long-Term Cognitive Trajectories in Relation to Incident Sarcopenia.Annals of geriatric medicine and research · 2026Article
- Associations of chronic lung disease, insufficient sleep, and pain with incident frailty in Chinese middle-aged and older adults.Epidemiology and health · 2026Article
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Abstract
backgroundWhile western studies suggest a temporal association between chronic pain and frailty, as well as the impacts of healthy lifestyle interventions, these relationships remain underexplored in the Chinese population.
methodsWe conducted a longitudinal study with 13,601 participants from the China Health and Retirement Longitudinal Study, covering 2011-2018. Pain was assessed via self-report, and frailty was evaluated using a 29-item deficit-accumulation frailty index. Five lifestyle factors, such as physical activity, alcohol consumption, smoking, body mass index, and sleep duration, were assessed, and the participants were categorized into favorable, intermediate, and unfavorable lifestyle groups.
resultsDuring the 7-year follow-up, 3,356 cases of frailty were discerned. Participants who reported pain at baseline assessment had a higher risk of developing frailty compared to those without pain (hazard ratio [HR] = 1.10; 95%confidence interval [CI], 1.03-1.19). This association was particularly evident in middle-aged individuals (HR = 1.13; 95% CI, 1.01-1.26). Participants with severe pain at baseline assessment had a 1.16-fold higher risk of frailty (95%CI, 1.05-1.28, P
conclusionsChronic pain is strongly associated with an increased risk of developing frailty in Chinese older population, but the implementation of healthy lifestyles can significantly reduce this risk.
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