Evidence map›Paper›PMID 40301161›Full record

ArticleJournal of bone and mineral metabolism2025

Non-contact electrical stimulation via a Vector-potential transformer promotes bone healing in drill-hole injury model.

Nao Yashima, Wataru Minamizono, Hiroya Matsunaga, Jiazheng Lyu, Kaoru Fujikawa, Hirai Suito, Takumi Okunuki, Shingo Nakai, Masafumi Ohsako

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nao YashimaGraduate School of Health and Sports Science, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo, 115-8650, Japan. s4h102300026@toyo.jp.ORCID http://orcid.org/0000-0002-6845-0740
Wataru MinamizonoGraduate School of Human Life Design, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo, 115-8650, Japan.
Hiroya MatsunagaGraduate School of Health and Sports Science, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo, 115-8650, Japan.
Jiazheng LyuGraduate School of Health and Sports Science, Toyo University, 1-7-11 Akabanedai, Kita-ku, Tokyo, 115-8650, Japan.
Kaoru FujikawaDepartment of Oral Anatomy, Showa Medical University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-0064, Japan.
Hirai SuitoDepartment of Anatomy, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Takumi OkunukiJapan Society for the Promotion of Science, Research Organization of Science and Technology, Ritsumeikan University, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan.
Shingo NakaiDepartment of Judo Seifuku and Health Sciences, Tokoha University School of Health Promotional Sciences, 1230 Miyakoda-cho, Hamana-ku, Hamamatsu-shi, Shizuoka, 431-2102, Japan.
Masafumi OhsakoDepartment of Health and Sports Science, Toyo University School of Health and Sports Science, 1-7-11 Akabanedai, Kita-ku, Tokyo, 115-8650, Japan.

Funding

Japan Science and Technology Agency JPMJSP2159
6 · The paper itself

Abstract

introductionWe investigated the effects of non-contact electrical stimulation via a Vector-potential (VP) transformer, a novel physical therapy device, on bone healing in drill-hole injury models. MATERIALS AND

methodsSix-week-old male Wistar rats, after a one-week acclimation period, were divided into three groups: the control group (CO), the bone injury group (BI), in which a drill-hole injury was created, and the VP stimulation group (VP), which received non-contact electrical stimulation via a VP transformer after bone injury. In the VP group, rats underwent stimulation at 200 kHz for 30 minutes per day, seven days per week.

resultsThe VP group exhibited increased bone formation as early as day 7 post-injury, with significantly higher bone volume than the BI group at all time points (day 7: p = 0.0003; day 14: p = 0.0024; day 21: p = 0.0001). By day 21, the VP group showed lighter toluidine blue staining and reduced biglycan immunoreactivity compared to the BI group. Bone mineral density also increased (p = 0.0008). Osteoblasts in the VP group displayed abundant cytoplasm and a high capacity for osteocalcin synthesis. Additionally, the VP group demonstrated increased expression of Bglap (day 5: p = 0.0068; day 7: p = 0.0096) and Ctsk (day 7: p = 0.0329; day 14: p = 0.0171), along with a higher number of TRAP-positive osteoclasts (day 21: p = 0.0159) compared to the BI group.

conclusionNon-contact electrical stimulation via a VP transformer promotes bone healing in drill-hole injury models.

Indexed as

Electric StimulationElectric Stimulation TherapyFracture HealingAnimalsBone DensityDisease Models, AnimalMaleOsteoblastsOsteogenesisRatsRats, WistarBone healingDrill-hole injury modelNon-contact electrical stimulationRatVector-potential transformer

Identifiers

PMID40301161
PMCPMC12279579

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.