Evidence map›Paper›PMID 40301158›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

The social determinants of health-related quality of life among people with chronic disease: a systematic literature review.

Terhi Kangas, Sara-Lynn Milis, Katrien Vanthomme, Hadewijch Vandenheede

Abstract readSystematic Review
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Impact of child loss on parents' health-related quality of life: evidence from the china health and retirement longitudinal study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  3. Factors independently associated with in-hospital HRQoL in adults treated at a high-complexity institution in a middle-income country.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  6. Explaining inequalities in quality of life: a longitudinal study of health disparities in Norway.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  8. The impact of health literacy on health-related quality of life among individuals with physical disabilities: a path analysis based on the integrated model of health literacy.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Terhi KangasBRISPO, Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, Brussel, 1050, Belgium. Terhi.kangas@vub.be.ORCID http://orcid.org/0000-0002-7936-9155
Sara-Lynn MilisBRISPO, Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, Brussel, 1050, Belgium.ORCID http://orcid.org/0000-0003-0646-0780
Katrien VanthommeDepartment of Public Health and Primary Care, Ghent University, Sint-Pietersnieuwstraat 33, Gent, Belgium.ORCID http://orcid.org/0000-0001-5861-3852
Hadewijch VandenheedeBRISPO, Department of Sociology, Vrije Universiteit Brussel, Pleinlaan 2, Brussel, 1050, Belgium.ORCID http://orcid.org/0000-0002-1134-8155

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis systematic review investigates the relationship between Social Determinants of Health (SDoH) and Health-Related Quality of Life (HRQoL) among individuals with chronic diseases. SDoH refer to the conditions in which people live, work, and interact, which are associated with health outcomes and inequalities. Understanding these determinants in the context of chronic diseases is essential for developing targeted interventions to improve their HRQoL.

methodsWe conducted a systematic review following PRISMA guidelines, searching PubMed, Web of Science, and Embase for original research articles published in English during the last 10 years. Studies included quantitative assessments of the relationship between SDoH and HRQoL in chronic disease populations. 38 studies met the eligibility criteria and were included in the analysis.

resultsSignificant bivariate associations between SDoH and HRQoL were observed. Younger age, male gender, higher social support, being married, higher education level, employment, higher income, and urban living were generally linked to better HRQoL. Multivariate analyses identified higher education and income as consistent predictors of better HRQoL when considered alongside other SDoH. Urbanization, age, and gender showed some mixed associations with HRQoL, highlighting the need for context-specific interventions.

conclusionThe findings underscore the critical role of SDoH in HRQoL among chronic disease populations. Policies aimed at improving HRQoL should consider multiple SDoH, particularly focusing on patients with low educational attainment living in low-income areas. However, variability in sample sizes and HRQoL measures complicate comparison. The predominance of cross-sectional studies limits the understanding of time-related effects, thus, future research should prioritize longitudinal studies.

Indexed as

Quality of LifeSocial Determinants of HealthChronic DiseaseFemaleHumansMaleMiddle AgedSocial SupportSocioeconomic FactorsChronic diseasesHealth-related quality of lifeSocial determinants of healthSystematic literature review

Identifiers

PMID40301158
PMCPMC12431912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.