Evidence map›Paper›PMID 40301146›Full record

ReviewSkeletal radiology2025

The role of molecular pathology in soft tissue tumor diagnosis: what the radiologist needs to know.

Naveen Parasu, Denny Mathew, Sharief Aboelmagd, Snezana Popovic, Hadas Benhabib

Abstract readReview
PubMed Publisher
In one paragraph

Review in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Naveen ParasuDepartment of Radiology, McMaster University, Hamilton, Canada.
Denny MathewDepartment of Radiology, McMaster University, Hamilton, Canada. denny.mathew@medportal.ca.
Sharief AboelmagdDepartment of Radiology, Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.
Snezana PopovicDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Hadas BenhabibDepartment of Radiology, McMaster University, Hamilton, Canada.ORCID http://orcid.org/0000-0002-3646-9156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For both general radiologists and those specializing in soft tissue sarcoma imaging, understanding the importance and basic concepts of molecular pathology is becoming increasingly relevant to current clinical practice. As molecular research identifies the most fundamental causes and markers of disease, diagnostic testing is increasingly focused on the cell nucleus and its genetic material. Identifying molecular abnormalities, such as mutations, deletions, and amplifications, has advanced our ability to diagnose genetic diseases, including a variety of cancers. Over the past two decades, molecular pathology has rapidly evolved, enhancing our understanding of sarcoma pathogenesis, diagnosis, and classification. This progress forms the foundation of the 2020 WHO classification of soft tissue and bone tumors. This article will highlight cases where molecular diagnostics are crucial for the definitive classification and diagnosis of select soft tissue tumors, with MRI correlation and key teaching points.

Indexed as

Magnetic Resonance ImagingPathology, MolecularSarcomaSoft Tissue NeoplasmsDiagnosis, DifferentialHumansHistomolecular tumor classificationImaging biomarkersMolecular diagnosticsSoft tissue sarcoma

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.