ArticleInternal medicine (Tokyo, Japan)2025
Vitamin C Deficiency Megaloblastic Anemia Mimicking Hemolytic Anemia.
Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Vitamin C Deficiency Can Present as True Hemolytic Anemia.Internal medicine (Tokyo, Japan) · 2026Article
- Response to Letter to the Editor: "Vitamin C Deficiency Can Present as True Hemolytic Anemia".Internal medicine (Tokyo, Japan) · 2026Article
- The Role of Vitamin C in Selected Autoimmune and Immune-Mediated Diseases: Exploring Potential Therapeutic Benefits.International journal of molecular sciences · 2025Review
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Authors and funding
7 authors.
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Abstract
A 31-year-old female presented at our hospital with fatigue and subcutaneous bleeding. Blood tests revealed hemolytic anemia. The patient had Coombs-negative normocytic anemia and thrombocytopenia; therefore, thrombotic thrombocytopenic purpura was ruled out. On day two, we noticed that the eating habits of the patient, hypersegmented neutrophils, and megaloblastic changes suggested malnutrition; therefore, we initiated vitamin supplementation. On day six, the vitamin C levels were <0.2 μg/mL, and the patient was therefore diagnosed with scurvy. Scurvy can mimic hemolytic anemia by causing normocytic megaloblastic anemia with a high reticulocyte count. Hypersegmented neutrophils and a detailed medical history are important for making a differential diagnosis.
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