Evidence map›Paper›PMID 40301042›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Electroconvulsive Therapy Can Prevent a Worsening of Psychosis and Dystonic Voice in PRKN-associated Parkinson's Disease.

Toshiki Tezuka, Kensuke Daida, Shinichiro Nakajima, Mika Konishi, Yoshihiro Nihei, Manabu Funayama, Kimberley J Billingsley, Cornelis Blauwendraat, Nobutaka Hattori, Hiroyuki Uchida and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Toshiki TezukaDepartment of Neurology, Keio University School of Medicine, Japan.
Kensuke DaidaDepartment of Neurology, Faculty of Medicine, Juntendo University, Japan.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Japan.
Mika KonishiParkinson's Disease Center, Keio University Hospital, Japan.
Yoshihiro NiheiDepartment of Neurology, Keio University School of Medicine, Japan.
Manabu FunayamaDepartment of Neurology, Faculty of Medicine, Juntendo University, Japan.
Kimberley J BillingsleyCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA.
Cornelis BlauwendraatIntegrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, USA.
Nobutaka HattoriDepartment of Neurology, Faculty of Medicine, Juntendo University, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Japan.
Jin NakaharaDepartment of Neurology, Keio University School of Medicine, Japan.
Morinobu SekiDepartment of Neurology, Keio University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electroconvulsive therapy (ECT), an established treatment for psychiatric disorders, shows promise in alleviating both motor and non-motor symptoms in patients with Parkinson's disease (PD). We herein report a case of PRKN-associated PD presenting with characteristic psychosis and dystonic voice, which was effectively managed with maintenance ECT. A genetic analysis initially identified a single heterozygous PRKN deletion using multiple ligation-probe amplification. Subsequent Oxford Nanopore technology long-read sequencing revealed a second pathogenic variant, confirming a compound heterozygous PRKN mutation. This case highlights the utility of long-read sequencing in resolving genetic diagnoses and the potential of maintenance ECT for managing complex PD phenotypes.

Indexed as

DystoniaElectroconvulsive TherapyParkinson DiseasePsychotic DisordersUbiquitin-Protein LigasesHumansMutationparkin proteinUbiquitin-Protein Ligaseselectroconvulsive therapylong-read sequencingParkinson's diseasePRKNpsychosis

Identifiers

PMID40301042
PMCPMC12659945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.